The influence of backbone fluorination and sidechain regiochemistry on an indacendithiophene (IDT) core containing electron withdrawing N-cyanoimine groups is investigated.

Positron emission tomography (PET) is unique in that it allows quantification of biochemical processes in vivo, but difficulties with preparing suitably labelled radiotracers limit its scientific and diagnostic applications. Aromatic [(18)F]fluorination of drug-like small molecules is particularly challenging as their functional group compositions often impair the labelling efficiency. Herein, ...

The viability of oxygen isotope analysis of tooth enamel by UV laser ablation and fluorination has been demonstrated by comparison with the Ag PO extraction method. In-situ analyses by UV laser fluorination using both isotope ratio mass 3 4 Ž . spectrometry and isotope ratio monitoring gas chromatography mass spectrometry irm-GCMS microanalysis are comparaŽ . 18 ble to those of the Ag PO method...

Despite the growing importance of fluorinated organic compounds in drug development, there are no direct protocols for the fluorination of aliphatic C-H bonds using conveniently handled fluoride salts. We have discovered that a manganese porphyrin complex catalyzes alkyl fluorination by fluoride ion under mild conditions in conjunction with stoichiometric oxidation by iodosylbenzene. Simple alk...

CF4 plasma-passivation enhanced size dependence of the blueshift in photoemission and photoabsorption, E2p-level shift, and band-gap expansion of porous silicon has been measured and analyzed numerically based on the recent “bond order-length-strength” correlation [C. Q. Sun, Phys. Rev. B 69, 045105 (2004)]. Matching predictions to the measurements conducted before and after fluorination reveal...

The outstanding characteristics of fluorine gas, e.g. extreme reactivity and oxidizing power, and the utmost electronegativity of F ion, lead to very strong bonds between fluorine and most of the other elements of the periodical table. Treatments involving F2, fluorinated gases and rf plasma-enhanced fluorination (PEF) constitute exceptional tools for modifying the surface properties of materia...

PR04.MZ 8-(4-fluoro-but-2-ynyl)-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (1) and LBT999 8-((E)-4-fluoro-but-2-enyl)-3b-p-tolyl-8-aza-bicyclo[3.2.1]octane-2beta-carboxylic acid methyl ester (2) are selective dopamine reuptake inhibitors, derived from cocaine. Compounds 1 and 2 were labelled with fluorine-18 at their terminally fluorinated N-substituents employing micro...

The benefits of covalent grafting fluorine atoms onto carbonaceous materials are described for the design new electrocatalysts low-temperature fuel cells. In order to obtain best results, fluorination conditions must be carefully chosen according physicochemical properties starting (specific surface area, pore size distribution, crystallinity, and doping). By describing main routes, article aim...