Overtreatment of prostate cancer (PC) remains one of the main burdens in uro-oncology. Focal therapy may be a reasonable alternative with less side effects and morbidity. Application of high-intensity focused ultrasound (HIFU) induces immediate and irreversible coagulation. The treatment leads to consecutive necrosis with sharply delineated margins, making HIFU a promising tool for the focal th...

Objective: To evaluate therapy effects and capability to preserve adjacent tissues of bilateral focal prostate ablation using Nd: YAG laser a canine model. Methods: 24 male Beagle dogs aged 3.9-7.4 years and weighting 9.4-12.1 kg were used in this study. The dogs underwent single focal Nd: YAG ablation. Applied the reasonable prostatic ablation parameters screened in the study and set different...

Myoglobinuria was found in an 11 month old girl suffering from fever, dyspnoea, and muscle hypotonia. Muscle biopsy showed focal degenerative necrosis of the muscle fibres. Electronmicroscopically, picornavirus-like crystals were demonstrated in the muscle fibres. These and other findings strongly suggest that she suffered from acute myositis with myoglobinuria probably caused by Coxsackie B6 v...

Histopathological alterations in kidneys have been studied in squirrels with repeated intraperitoneal injections of cadmium acetate at a dose of 1.0 mg Cd/Kg of body weight. Cloudy swelling, necrosis, denudation and destruction of tubular epithelium, focal aggregates of inflammatory cells, perivascular inflammation by chronic inflammatory cells and perinephric haemorrhage with infiltration by p...

Telangiectasia-associated hepatic fibrosis (TAHF) in a 68-year-old woman with hereditary haemorrhagic telangiectasia (HHT) is described. The patient died of oat-cell carcinoma of the lung. In addition to the structural alterations which have been described previously in HHT, the liver exhibited focal midlobular hepatocytic necrosis and tumour metastases. The possibility that treatment of HHT wa...

Multiple necrotic hepatitis lesions of 5 newly hatched broiler chicks in three flocks derived from two hatcheries were examined pathologically. The livers were brittle, and multiple yellowish or green foci were scattered on the surface and cut surface. The main histological finding was well demarcated multi-focal necrosis in the liver. Many Gram-positive large bacilli that reacted positively wi...

Skin necrosis caused by heparins is a rare complication. We report a case of a 71-year-old woman who developed the unusual complication of focal necrotizing skin lesions in the injection site after undergoing thromboprophylaxis with enoxaparin after right knee arthroplasty. Laboratory investigations for heparine-induced thrombocytopenia (HIT), disseminated intravascular coagulation, protein C, ...

Atypical (bizarre) leiomyoma is a benign uterine smooth-muscle tumor characterized by a) a significant number of cells with dense eosinophilic cytoplasm and enlarged, bizarre single/multiple hyperchromatic or multiple nuclei without tumor necrosis and b) poor mitotic activity. We report the case of an atypical (bizarre) leiomyoma revealed by focal fluoro-deoxyglucose (FDG) uptake during a PET-C...

A case is reported in which several days afiter a relautvely minor closed head injury progressive, fatal neurological deterioration set in. Necropsy showed spreading oortical uhrombophlebitis originating from a small area of cerebral contusion. Some cases of progressive focal cerebral oedema and necrosis occurring after head injury mnight have a similar pathological basi's, and if this were so ...

ABs'rRAcr. Nine aborted t'ctuses and orrc newborn calf, diagnosed as Chlamydia psittaci (C. psittaci) infection, were pathologica]ly examined. Thc characteristic lesions in the liver were focal necrosis in 9 aborted fetuses anci granulomatot]s necrotic foci in the newborn ca]f, Moderate numbers of intranuclcar inclusion bodies werc found in necrotic foci of the]iver, spleen, thymus, ]ymph nodes...