INTRODUCTION Seizures are most commonly associated with positive phenomena such as tonic, clonic or myoclonic movements, automatisms, paresthesias and hallucinations. Negative phenomena, however, are not an uncommon manifestation of seizure activity. Examples of negative seizure phenomena include speech arrest, aphasia, amaurosis, amnesia, numbness, deafness, neglect and atonic seizures. Less c...

OCCASIONAL SPECIMENS of scarred, atrophic brain removed for the relief of focal cerebral seizures at the Montreal Neurological Institute have shown striking perivascular collections of round cells, particularly in less severely damaged areas of these specimens. In the past this perivascular cuffing has been attributed to the effect on the brain of recurring seizures, with recognition, however, ...

Abstract Background Stroke had been accounted to cause almost 50% of epilepsy in the elderly and may lead poor functional outcomes. Many studies examining risk factors have conducted despite showing inconsistent results currently still difficult predict occurrence post-stroke epilepsy. The study aimed determine related that influence clinical seizure, electroencephalography (EEG), outcome patie...

Circadian rhythm of seizure is underestimated in the study of focal epilepsies. A review of the current literature revealed a clear correlation between cortical epileptogenic focus and the circadian phase of seizure peak occurrence in adult patients. A single diurnal peak at 19:00 was found in seizures originating from the occipital lobe, between 5:00 and 7:00 in frontal lobe seizures, and betw...

Mutations of the LGI1 (leucine-rich, glioma-inactivated 1) gene underlie autosomal dominant lateral temporal lobe epilepsy, a focal idiopathic inherited epilepsy syndrome. The LGI1 gene encodes a protein secreted by neurons, one of the only non-ion channel genes implicated in idiopathic familial epilepsy. While mutations probably result in a loss of function, the role of LGI1 in the pathophysio...

Polyopia is the visual perception of multiple images of a single visual stimulus. Cerebral polyopia has previously been described as an ictal phenomenon associated with temporal lobe seizures. We report the case of a man with multiple cavernous angiomas and occipital lobe seizures manifesting as cerebral polyopia.

Impaired consciousness in temporal lobe seizures has a major negative impact on quality of life. The prevailing view holds that this disorder impairs consciousness by seizure spread to the bilateral temporal lobes. We propose instead that seizures invade subcortical regions and depress arousal, causing impairment through decreases rather than through increases in activity. Using functional magn...

Focal epilepsy is commonly pharmacoresistant, and resective surgery is often contraindicated by proximity to eloquent cortex. Many patients have no effective treatment options. Gene therapy allows cell-type specific inhibition of neuronal excitability, but on-demand seizure suppression has only been achieved with optogenetics, which requires invasive light delivery. Here we test a combined chem...

OBJECTIVE To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy modeling showing superior efficacy for pregabalin. METHODS The design of this comparative efficacy and safety study of pregabalin and gabapentin as adjunctive treatment in adults with refractory partial-onset ...

Case presentation: Male, 6 years old, presenting seizures since the age of 4 and evolving with refractory epilepsy, in use several medications for focal seizures, including Lacosamide, Cannabidiol, Phenobarbital Sulthiame. A 24-hour electroencephalogram showed bursts bilateral sharp waves front rolandic region, no adequate localization epileptogenic zone. Resonance imaging examination revealed ...