Abbreviations 1-MA 1-methyladenine AC adenylate cyclase cADPr cyclic ADP-ribose CaMKII calcium/calmodulin-dependent kinase DHP 17,20b-dihydro-4-pregnen-3-one ER endoplasmic reticulum ES cells embryonic stem cells FF-MAS follicular fluid meiosis-activating sterol FSH follicle-stimulating hormone GPCR G-protein coupled receptor

The reason ovarian function and fertility are diminished in women with a low antral follicle count (AFC), despite significant numbers of follicles remaining in ovaries, is unknown. The bovine model is unique to address this question because cattle and women with a low AFC exhibit similar phenotypic characteristics including a diminished ovarian reserve, reduced circulating concentrations of ant...

Background: Follicle stimulating hormone (FSH) receptor plays an important role in FSH signaling during reproductive development. Any changes in FSHR gene is resulted in alteration of amino acid in protein chain, consequence to affect the binding affinity, intracellular signaling and expression levels of FSHR. FSHR polymorphisms can be involved in etiology of many reproductive disorders such as...

The authors report the generation, structure and function of a fully humanized, humanized antibody that profoundly inhibits follicle-stimulating hormone (FSH) actions in cell-based assays. Administration to ovariectomized mice prevented bone loss also accumulation adipose tissue when fed high-fat diet (HFD).

BACKGROUND The purpose of this study was to investigate the potential association between socioeconomic status and ovarian reserve, anti-Mullerian hormone level, antral follicle count, and follicle stimulating hormone level in women of reproductive age. MATERIAL AND METHODS A total of 101 married women between 20-35 years of age who presented to the Department of Obstetrics and Gynecology, Heal...

The objective of the present study was to detect polymorphism in follicle stimulating hormone receptor (FSHR) and beta subunit of follicle stimulating hormone (FSHβ) genes and their relation to litter size and body weight trait in Baluchi, Iran black and Arman sheep breeds. PCR-RFLP technique using ACCI and HinfI enzyme treatments employed to detection of polymorphism in FSHβ marker site but de...