نتایج جستجو برای: formulation excipients
تعداد نتایج: 112735 فیلتر نتایج به سال:
Discovery of novel cocrystal systems and improvement their physicochemical properties dominates the current literature on cocrystals yet required end-product formulation is rarely addressed. Drug product manufacturing includes complex API solid state processing steps such as milling, granulation, tableting. These all require high mechanical stress which can lead to solid-state phase transformat...
Case-Based Reasoning is a recent Artificial Intelligence problem-solving methodology where new problems are solved by re-using solutions to similar problems in the past. We use this approach to address the formulation problem for tablets: given the dose of a particular new drug decide which excipients to use as filler, binder, disintegrant, lubricant and surfactant, and the quantity of each, so...
The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornoxicam and e...
This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in early stage amorphous solid dispersion(ASD) system development by profiling excipients’ capability to solubilise, amorphisise, stabilise chosen active pharmaceutical ingredient (API) an effort rank their suitability. Lumefantrine, antimalarial compound with both poor sol...
Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 sec using super-disintegrants, special polymers, water soluble and even inso...
AIn this study a simple and reliable stability-indicating RP-HPLC method was developed and validated for analysis of Dexpanthenol in an artificial tear formulation. The chromatographic separation was performed on a HPLC C18 column (25.0 cm 4.6 mm, 5 m) using a mixture of 0.037 M monobasic potassium phosphate in water (adjusted with 0.1% (v/v) phosphoric acid to a pH of 3.2) and methanol (90:...
AIn this study a simple and reliable stability-indicating RP-HPLC method was developed and validated for analysis of Dexpanthenol in an artificial tear formulation. The chromatographic separation was performed on a HPLC C18 column (25.0 cm 4.6 mm, 5 m) using a mixture of 0.037 M monobasic potassium phosphate in water (adjusted with 0.1% (v/v) phosphoric acid to a pH of 3.2) and methanol (90:...
To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, ...
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