Abstract Costal bridge systems usually contain tall piers with heights over 40 m, due to the engineering site exposed deep water circumstances. Note that conventional seismic isolation devices (e.g., bearings) are not effective for piers, since their dynamic performance is significantly affected by distributed mass and vibration modes of columns; therefore, base design philosophy could be a pro...

Fragility analysis of structures via numerical methods involves a complex trade-off between the desired accuracy, explicit consideration uncertainties (both epistemic and aleatory) related to structural model available computational performance. This paper introduces framework for deriving fragility relationships based on multi-fidelity non-linear models structure under investigation response-a...

Background Hair is an ectodermal structure, and its formation is regulated by master genes important in embryology. Hair shaft consists of three major regions: the medulla, cortex and cuticle. Hair shaft abnormality will divide structural hair abnormalities into two broad categories - those associated with increased hair fragility and those not associated with increased hair fragility. We condu...

The restrictive assumptions imposed by the traditional methods of aggregation prevented so far a sound analysis of complex system of feedback between microeconomic variables and macroeconomic outcomes. This issue seems to be crucial in macroeconomic modelling, in particular for the analysis of financial fragility, as conceived in the Keynesian and New Keynesian literature. In the present paper ...

Although it is recognized that red cells lose membrane during storage, estimation of the osmotic fragility of erythrocytes has not previously proven to be a useful measurement of the storage lesion. Erythrocytes from blood stored in CPD-A2 were found to have a markedly increased osmotic fragility. A major portion of this increase was found to be due to accumulation of lactate, which is only slo...