Frailty is measured to understand its nature and biology, to aid diagnosis and care planning, to measure outcomes and to stratify risk. Such goals oblige two types of frailty measures - for screening and for assessment - and recognition that not all measures will serve all purposes. When the goal is broad identification of people at risk, a dichotomised approach (frailty is present or absent ) ...

Frailty is an important outcome predictor in older patients. We randomly sampled 12,000 veterans with heart failure diagnosed in 2010. The topic modeling method was applied to identify frailty-related topics from the clinical notes in the electronic medical records. The frailty topics were classified into five deficit areas including physical functioning (PF), role-physical (RP), general health...

Corresponding author Fabiana de Souza Orlandi Rodovia Washington Luis, km 235, São Carlos, SP, Brazil. CEP: 13565-905 [email protected] Universidade Federal de Sao Carlos, Sao Carlos, SP, Brazil. Conflicts of interest: there are no conflicts of interest to declare. Abstract Objective: To assess the frailty level of elderly people with chronic kidney disease undergoing hemodialysis. Met...

BACKGROUND Age-associated decline in testosterone levels represent one of the potential mechanisms involved in the development of frailty. Although this association has been widely reported in older men, very few data are available in women. We studied the association between testosterone and frailty in women and assessed sex differences in this relationship. METHODS We used cross-sectional d...

BACKGROUND Frailty in the elderly increases their vulnerability and leads to a greater risk of adverse events. According to various studies, the prevalence of the frailty syndrome in persons age 65 and over ranges between 3% and 37%, depending on age and sex. Walking speed in itself is considered a simple indicator of health status and of survival in older persons. Detecting frailty in primary ...

The Veterans Aging Cohort Study (VACS) Index has previously been used to identify frail HIV-infected persons. However, data demonstrating the independent association between the VACS Index and baseline frailty status is lacking. Furthermore, the ability of the VACS Index to also reflect transitions in frailty status over time is unknown. We used data from the Study to Understand the Natural His...

Frailty is a relatively young area of investigation in cardiovascular research. The first wave of published research, circa 2001 to 2006, uncovered the epidemiological and pathophysiological links between frailty and cardiovascular disease (CVD). Compared to those without CVD, older adults with CVD were reported to have an odds ratio of 2.7 to 4.1 for prevalent frailty in cross-sectional studie...

BACKGROUND Frailty is a predictor of poor outcomes following many types of operations. We measured thoracic surgeons' accuracy in assessing patient frailty using videos of standardized patients demonstrating signs of physical frailty. We compared their performance to that of geriatrics specialists. METHODS We developed an anchored scale for rating degree of frailty. Reference categories were ...

The concept of frailty plays a major role in the statistical field of survival analysis. Frailty variation refers to differences in risk between individuals which go beyond known or measured risk factors. In other words, frailty variation is unobserved heterogeneity. Although understanding frailty is of interest in its own right, the literature on survival analysis has demonstrated that existen...

We aimed to determine whether frailty, a validated geriatric construct of increased vulnerability to physiologic stressors, predicts mortality in liver transplant candidates. Consecutive adult outpatients listed for liver transplant with laboratory Model for End-Stage Liver Disease (MELD) ≥ 12 at a single center (97% recruitment rate) underwent four frailty assessments: Fried Frailty, Short Phy...