OBJECTIVES To assess whether there is a need to correct first-trimester biochemical markers (free beta-hCG and pregnancy-associated plasma protein-A (PAPP-A)) or first-trimester fetal nuchal translucency thickness (NT) in different ethnic groups, when screening for Downs syndrome at 11-14 weeks of gestation. METHODS Free beta-hCG, PAPP-A and fetal NT were measured at 11-14 weeks of gestation ...

Maternal serum analyte screening is an integral component of contemporary antenatal care. Based on elevated MSAFP levels, 85% to 90% of NTDs (e.g., anencephaly or spina bifida) can be detected. Using a combination of serum analytes (e.g., MSAFP, hCG, UE3) 55% to 60% of fetal Down's syndrome can be detected. Future strategies for Down's syndrome screening may include the use of new markers such ...

We report a histologically pure stage 1 seminoma with an elevated human chorionic gonadotropin (hCG). A 38 year-old man was referred for the evaluation of the left testicular swelling. He showed an elevated serum hCG level of 25,265 mIU/ml with normal a fetoprotein and lactate dehydrogenase. Imaging showed heterogeneous tumor without any metastatic lesions. We conducted 4 courses of chemotherap...

The structures of the 4 asparagine-linked carbohydrate units of aand P-subunits of human chorionic gonadotropin (hCG-a and hCG+) have been determined by carrying out the structural investigations on the tryptic glycopeptides (uT-8, aT-lla, p-2, and pT-3 (Bellisario, R., Carlsen, R. B., and Bahl, 0. P. (1973) J. Biol. Chem. 248, 6796-6809; Carlsen, R. B., Bahl, 0. P., and Swaminathan, N. (1973) ...

We investigated whether insulin plays a role in the proliferation and androgen production of chick testis cells. Testes from 18-d-old chick embryos or newly hatched chickens were dissociated and precultured in the presence of fetal bovine serum (FBS) for 24 h. After this period, testis cells from 18-d-old chick embryos were cultured in serum-free medium for 1 h with 0, 10, 50, or 100 microg/mL ...

The effects of sex hormone-binding globulin (SHBG) on the secretion of human chorionic gonadotrophin (HCG) and cAMP by cultured human cytotrophoblasts were investigated. Cytotrophoblasts obtained from normal term placentae were cultured in serum-free medium with or without the addition of human SHBG. The presence of SHBG in the medium increased the release of HCG and the accumulation of cAMP. L...

A selection of artificial neural network models were built and implemented for systematically study the contribution and the sensitivity of the main influencing parameters as important contributing factors for the noninvasive prediction of chromosomal abnormalities. The parameters that had been investigated are: the previous medical history of the pregnant mother, the nasal bone, the tricuspid ...

We demonstrate efficient optical modulation of surface-normal reflection in a novel device structure integrating graphene on a high contrast grating (HCG) resonator. As high as 11 dB extinction ratio is achieved by varying the voltage applied to a single atomic layer of graphene on a HCG resonator. The device topology facilitates easy fabrication of large 2D arrays, and free-space operation. We...

In an attempt to localize topographic domains specific to native human chorionic gonadotropin (hCG), we studied the discontinuous antigenic regions recognized by a monoclonal anti-hCG antibody designated as C8 which binds only to hCG and does not cross-react with either the free hCG-alpha and hCG-beta subunits or other glycoprotein hormones. Using two-site monoclonal immunoradiometric assays (M...