Femtosecond to picosecond dynamics of enzyme active sites is relatively unknown. With the advent of two-dimension infrared spectroscopy, it is now possible to characterize thermally activated motions at this time scale in functionally relevant enzyme complexes. We present a series of measurements on complexes of formate dehydrogenase (FDH) using transitional-state analog inhibitor azide as a re...

Familial dyslipidemic hypertension (FDH) Is a syndrome recently described from sibshlps selected for early familial hypertension and found to have one or more of three fasting llpld abnormalities [high trlglycerldes, low high density lipoprotein (HDL) cholesterol, high low density lipoprotein (LDL) cholesterol]. In further analyses of these same 131 hypertensive subjects, apolipoprotein A-l and...

The Full Domain Hash (FDH) scheme is a RSA-based signature scheme in which the message is hashed onto the full domain of the RSA function. The FDH scheme is provably secure in the random oracle model, assuming that inverting RSA is hard. In this paper we exhibit a slightly different proof which provides a tighter security reduction. This in turn improves the efficiency of the scheme since small...

10-Formyltetrahydrofolate dehydrogenase (FDH) is composed of three domains and possesses three catalytic activities but has only two catalytic centers. The amino-terminal domain (residue 1-310) bears 10-formyltetrahydrofolate hydrolase activity, the carboxyl-terminal domain (residue 420-902) bears an aldehyde dehydrogenase activity, and the full-length FDH produces 10-formyltetrahydrofolate deh...

Focal dermal hypoplasia (FDH) is a rare disorder of the mesodermal and ectodermal tissues. Here we present an eight-year-old female known to have FDH who presents with poor weight gain and dysphagia. She was diagnosed with multiple esophageal papillomas and eosinophilic esophagitis. She was successfully treated with argon plasma coagulation and ingested fluticasone propionate, which has not bee...

Enzymes have become important tools in several industries due to their ability to produce chirally pure and complex molecules with interesting biological properties. The NAD(+)-dependent LDH (lactate dehydrogenase) [bsLDH [Geobacillus stearothermophilus (formerly Bacillus stearothermophilus) LDH] from G. stearothermophilus and the NAD(+)-dependent FDH (formate dehydrogenase) [cmFDH (Candida met...

A class of Nash implementation problems of particular economic interest is that of implementing the core in games of pure allocation, or ‘cake division’. Mechanisms that have been proposed to solve this type of problem often involve off-equilibrium ‘punishments’ that lie in the interior of the feasible set; that is, in which not all the cake is allocated. They also tend to make use of extraneou...

P aediatricians are frequently asked to see children who cause concern because of their slow growth or development. In this situation, despite the absence of any specific abnormal signs, thyroid function tests are commonly requested. They are nearly always normal. We describe three patients, where abnormal results led to erroneous treatment for thyrotoxicosis. These patients had a diagnosis of ...

Governments of developing countries typically spend between 15 and 30 percent of GDP. Hence, small changes in the efficiency of public spending could have a major impact on GDP and on the attainment of the government’s objectives. The first challenge that stakeholders face is measuring efficiency. This paper attempts such quantification and has two major parts. The first one estimates efficienc...