A father recounts a transformative journey of love, loss, and learning as his son developed and eventually died of a fungal infection that occurred during a period of immunocompromise after a bone marrow transplantation to treat hypodiploid leukemia. He then thanks the many physicians, researchers, family members, and friends who came together to memorialize his son and create knowledge, hope, ...

Maria became queen on the death of her father from a stroke in 1776 and reversed many of the changes wrought by Pombal. Apart from an isolated episode of delirium in 1781, her first symptoms of mental ill health occurred in 1788 following the deaths from smallpox of her elder son and of her daughter and husband and their infant son; Maria felt considerable guilt as she had opposed smallpox inoc...

Neurofibromatosis is a collective name for a group of genetic conditions in which benign tumours affect the nervous system. Type 1 is caused by a genetic mutation in the NF1 gene (OMIM 613113) and symptoms can vary dramatically between individuals, even within the same family. Some people have very mild skin changes, whereas others suffer severe medical complications. The condition usually appe...

Alexander Porfiryevich Borodin (Figure 1) was born on November 12, 1833, in the capital of the Imperial Russia St. Petersburg, as a rejected and illegitimate son of 62-year-old Georgian prince Luka Gedevanishvili (according to one historical source) or prince Luka Stepanovich Gedeonov (second historical source) and a 37 years younger Russian peasant Evdokia Konstantinovna Antonovna. The father ...

BACKGROUND The mitotic and meiotic behaviour of a transmitted ring Y [r(Y)] chromosome from a father to his Klinefelter syndrome (KS) son, and the mechanism of ring formation are analysed herein. To our knowledge, this is the first reported case of natural transmission of an r(Y). METHODS AND RESULTS Amplification of X chromosome polymorphisms by PCR showed that the KS was of paternal origin....