Allergic asthmatic individuals are often exposed to low-doses of allergen in their everyday life. Extended exposure to allergen has lead to down-regulation of the allergic process in cell systems and in animal models. The aim of this study was to evaluate whether any such inhibitory mechanism of allergic responses can be seen in man in vivo. Patients with mild asthma were repeatedly and double-...

BACKGROUND Allergen-specific IgE production is a hallmark of allergic asthma/rhinitis/eczema. Theoretically this could be due to a high number of allergen-specific B cells or allergen-specific T cells helping allergen-specific B cells differentiate into IgE-producing plasma cells. Here, we determined whether the number of allergen-specific B cells or T helper (Th) cells is higher in allergic in...

PS 401‐8 Exposure Assessment of Legionella pneumophila in Nursing Homes of Taiwan C. Chang, N. Chen, Y. Wu, K. Ming, National Taiwan University, Taipei, Taiwan. Objective: An investigation was conducted to assess the exposure risk to Legionella pneumophila in eight nursing homes of Taiwan. Methods: Hot water (HW) and swab samples were taken from the faucets and shower heads. As for cooling tow...

Experimental mouse models of asthma have broadened our understanding of the mechanisms behind allergen-induced asthma. Typically, mouse models of allergic asthma explore responses to a single allergen; however, patients with asthma are frequently exposed to, and tend to be allergic to, more than one allergen. The aim of the current study was to develop a new and more relevant mouse model of ast...

Allergen food recalls issued by regulatory bodies in the UK from 2016 to 2021 are analysed herein type, allergenic group, reasons for recall, and expiry status. Trends relationships have been assessed. Food allergen-related tended increase annually despite increased awareness regulations until 2019, peaking at 118 before decreasing 82 84 2020 respectively. Recalls due allergens were main reason...

BACKGROUND Skin prick test (SPT) and specific IgE (sIgE) are approved for evaluation of allergen sensitization. Local allergen extracts are less expensive and more available but need to be standardized. OBJECTIVE To compare SPT results of local and imported allergen extracts and sIgE levels in response to the American cockroach, dog, cat, Dermatophagoides pteronyssinus (Dp), Dermatophagoides ...

Introduction: Why can a peanut allergy cause exceptionally severe reactions, but not to everyone? Is there way identify patients who might experience these reactions? What is molecular diagnostics of and what are the benefits diagnosing at risk anaphylaxis after consuming peanuts? Purpose: The aim study show allergies based on example allergy.Description state knowledge: diagnosis assessment cl...

BACKGROUND Allergen exposure via the respiratory tract and in particular via the nasal mucosa boosts systemic allergen-specific IgE production. Intranasal corticosteroids (INCS) represent a first line treatment of allergic rhinitis but their effects on this boost of allergen-specific IgE production are unclear. AIM Here we aimed to determine in a double-blind, placebo-controlled study whether...

BACKGROUND Patients with atopic dermatitis may experience exacerbations of eczema triggered by various inflammatory stimuli. One mechanism may be IgE-mediated reactions to dermatophytes since these patients are more likely to acquire skin infections with dermatophytes and may become sensitized. OBJECTIVE This study investigates IgE-sensitization to fungi in patients with atopic dermatitis and...

Although initially investigated for its antifungal properties, little is actually known about the effect of gliotoxin on Aspergillus fumigatus and other fungi. We have observed that exposure of A. fumigatus to exogenous gliotoxin (14 μg/ml), under gliotoxin-limited growth conditions, results in significant alteration of the expression of 27 proteins (up- and down-regulated >1.9-fold; p<0.05) in...