Background Breast cancer causes the most number of deaths in females worldwide.[1] It contributed to 14% of cancer deaths in 2008 and is also the most commonly diagnosed cancer in women globally. Overexpression of the tight junction protein junctional adhesion molecule-A (JAM-A) in breast cancer tissue is known to produce less favourable outcomes in breast cancer patients. Overexpressed JAM-A m...

Junctional adhesion molecule-C (JAM-C) is an adhesion molecule expressed by endothelial cells (ECs) that plays a role in tight junction formation, leukocyte adhesion, and transendothelial migration. In the current study, we investigated whether JAM-C is found in soluble form and whether soluble JAM-C (sJAM-C) mediates angiogenesis. We found that JAM-C is present in soluble form in normal serum ...

The genetic relation among different populations and breeds of goats in Bangladesh was studied using 15 microsatellite markers. A total of 181 goat samples36 from Black Bengal of western part (BBW), 39 from Black Bengal of central part (BBC), 40 from Black Bengal of Hilly region (BBH), 28 from exotic breeds (JAM) and 39 from crossbred (CRW) were genotyped. The allele number per locus ranged fro...

Here, we define an endothelial cell (EC) lumen signaling complex involving Cdc42, Par6b, Par3, junction adhesion molecule (Jam)-B and Jam-C, membrane type 1-matrix metalloproteinase (MT1-MMP), and integrin alpha(2)beta(1), which coassociate to control human EC tubulogenesis in 3D collagen matrices. Blockade of both Jam-B and Jam-C using antibodies, siRNA, or dominant-negative mutants completely...

Large scale traffic congestion often stems from local traffic jam in single road or intersection. In this paper, macroscopic method was used to explore the formation and propagation of local traffic jam. It is found that (1) the propagation of traffic jam can be seen as the propagation of traffic signal parameters, that is, virtual split and virtual green time; (2) for a road with endogenous fl...