A simple heated precolumn device constructed from standard gas chromatographic components is described and evaluated. The device permits the analysis of concentrations of anaesthetic agents by direct injection of whole blood containing a suitable internal standard. A method is described for the analysis of halothane, chloroform, trichloroethylene, and methoxyflurane. The procedure is rapid and ...

Serum quinidine concentrations were determined in patients on chronic therapeutic doses. Although results were higher by a protein precipitate-fluorescence method as compared to a specific extraction fluorescence method, there was substantial correlation between results by the two methods (r = 0.945, P less than 0.001). We established the specificity of the extraction method by a methylation ga...

Although cellular alterations occurring during infection may reflect a general response to perturbation associated with pathogenesis rather than a specific response to the virulent agent (1, 2), the biochemical changes effected in the host by a pathogen may be highly specific and detectable by ultrasensitive gas-liquid chromatographic (glc) techniques (3, 4). However, such chromatographic analy...