Reactive oxygen species (ROS) are thought to be involved in the gastric ulcer formation induced by indomethacin, a typical nonsteroidal anti-inflammatory drug. However, the location and the time course of ROS generation remain unknown. To assess the sites of ROS generation, we applied the noninvasive measurement of ROS to indomethacin-treated rats. By giving orally a membrane-permeable or imper...

The term 'cytoprotection' means protection against gastric mucosal injury by a mechanism other than inhibition or neutralisation of gastric acid. Several mechanisms of gastric cytoprotection have been proposed like increased mucus and bicarbonate secretion, strengthening of gastric mucosal barrier, increased gastric mucosal blood flow, decreased gastric motility, increased formation of prostagl...

BACKGROUND Prostaglandin endoperoxide synthase/cyclooxygenase (COX) is the key enzyme in gastric mucosal protection and repair but its cellular localisation in the human stomach is still unclear. AIMS To investigate immunohistochemically the cellular distribution of COX-1 and COX-2 proteins in the human stomach with or without gastritis or ulceration. PATIENTS AND METHODS Tissues were obtai...

The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was evalu...

BACKGROUND Prostaglandin E which is present abundantly in the gastric mucosa is a powerful inhibitor of gastric acid secretion and a stimulus to gastric mucus production. In addition, prostaglandin E2 inhibits ulcer formation in animals, and the synthetic analogues of prostaglandin E have successfully been used in the treatment of patients with gastric and duodenal ulcer disease. To evaluate th...

Ficus religiosa L (Moraceae) is widely distributed in northern part of India has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Ficus religiosa L was used for investigation of antiulcer activity by using pylorus ligation as antisecretory model and ethanol induced ulceration models as cytoprotective mode...

Peptic ulcer is common in present days due to stress and anxiety. Peptic ulcer is thought to result from an imbalance between acid-pepsin secretion and mucosal defense factors. Though currently available drugs provide adequate relief from pain, promote healing, the problem of relapse has eluded success. The present study was designed to evaluate the combination effect of melatonin with lansopra...

background the importance of sialic acid binding adhesin (saba) as a new outer membrane protein in gastroduodenal diseases has been recognized. the prevalence rate of saba gene varies in different geographic areas. objectives the aim of this study was to determine the frequency of saba gene in helicobacter pylori (h. pylori) strains isolated from different clinical outcomes in tehran, iran. pat...

The variations in size of the alkaline area of the gastric mucosa in disorders such as gastric ulcer, duodenal ulcer, and combined gastric and duodenal ulcer have been reported previously (Capper, Laidlaw, Buckler, and Richards, 1962; Capper, Butler, Buckler, and Hallett, 1966). The areas were defined at operation using a pH monitoring system, and were confirmed histologically afterwards. Recen...

In normal, duodenal ulcer, and gastric ulcer subjects the two main forms of gastrin, G17 and G34, were estimated by radioimmunoassay in fasting serum and after feeding. Two antisera were used: one showing high specificity for G17, the other specific for the common COOH-terminus of G17 and G34 and so allowing estimation of G34 by difference. Basal G17 was similar in gastric ulcer, duodenal ulcer...