Agnitundirasa was tested for antigastric ulcer activity in shay rat model. Oral dose of 10 mg/kg reduced the ulceration in shay rat. With 20mg/kg dose the ulceration was completely absent. The antigastric ulcer activity of agnitundirasa (20 mg/kg) was found to be equal to the effect produced by cimetidine (20 mg/kg). The reduction in gastric acidity was more with cimetidine and the reduction in...

Expression of cyclooxygenase-2 (Cox-2) is elevated in gastric adenocarcinomas and precursor lesions leading to this disease. Mice deficient for trefoil factor 1 (TFF1) develop a pyloric adenoma with full penetrance. Because inhibition of Cox-2 suppresses tumor growth in several animal models, we studied expression of Cox-2 and effect of a selective Cox-2 inhibitor celecoxib in gastrointestinal ...

Tiao He Yi Wei granule (DHYW), a traditional Chinese medicine, has been used for the treatment of gastric ulcer in clinical setting. The purpose of the present study was to investigate the possible effect of DHYW and explore the underlying mechanism against ethanol-induced gastric ulcer in mice. The model of ethanol-induced gastric ulcer in mice was induced by ethanol (0.2 mL/kg). Administratio...

Non-steroidal anti-inflammatory drugs cause gastric ulceration through a number of mechanisms including inhibition of PG synthesis, generation of reactive oxygen species (ROS) and induction of apoptosis. Recently, matrix metalloproteinases (MMP) have been suggested to play a crucial role in these mechanisms. The present study investigated the protective effect of anthocyanins isolated from blac...

OBJECTIVE To test the hypothesis that the neurohormone, melatonin, differentially activates the release of the proinflammatory cytokines, such as, interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as inducing leukocyte mobilization into the peripheral blood in response to a sterile tissue injury. METHODS This study was conducted between November 2011 and Septe...

A case is reported showing enlargement of the salivary gland with hypersecretion and Brunner's gland hyperplasia in the Zollinger-Ellison syndrome. Gastric hypersecretion and diarrhoea were prominent, but there was no peptic ulceration.

An 80-year-old woman developed osteoarthritis of the knees as a complication of her obesity. Indomethacin treatment precipitated gastric ulceration, which led to the formation of a gastro-colic fistula.

A 59-year-old man, with a history of Roux-en-Y gastric bypass 9 years previously, presented with chronic epigastric pain thought to be due to recurrent marginal ulceration. On diagnostic endoscopy he was found to have a 3-cm gastric pouch and a 18-mm gastrojejunal anastomotic diameter. Additionally, a 1-cm cratered ulceration on the jejunal aspect of the post-bypass anastomosis and a 3-mm fistu...

The presence of ascorbic acid in gastric juice may protect against gastric carcinoma and peptic ulceration. This study examined the effect of Helicobacter pylori (H pylori) on the secretion of ascorbic acid into gastric juice by measuring fasting plasma and gastric juice ascorbic acid concentrations in patients with and without the infection and also before and after its eradication. Gastric ju...