Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for gene-metformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates ...

Modulating the interaction between small gas molecules and solid host materials is becoming increasingly important for the future society due to the alternative energy resources especially for the hydrogen energy. As is known, two catalogues of materials such as two-dimensional (2D) lamellar cavity structures and three-dimensional (3D) infinite tunnel structures have received intensive consider...

T he largest barrier reef in the world, Australia’s Great Barrier Reef (GBR), extends for over 2,300 km and encompasses nearly 3,000 individual reef formations. An ecosystem of extraordinary diversity and beauty (Fig. 1A), it is aWorld Heritage Site that brings substantial resources to the Australian economy, including over 50,000 full-time jobs and A$5.5 billion annually (1). It is also widely...

MODELING OF FLEXIBLE DRUG-LIKE MOLECULES: QSAR OF GBR 12909 ANALOG DAT/SERT SELECTIVITY by Kathleen Mary Gilbert The dopamine reuptake inhibitor GBR 12909 and related dialkyl piperazine and piperidine analogs have been studied as agonist substitution therapies acting on the dopamine transporter (DAT) to treat cocaine addiction. Undesirable binding to the serotonin transporter (SERT) can vary gr...

PURPOSE The aim of the present randomized controlled clinical study was to test whether small bony dehiscence defects (≤5 mm) left to heal spontaneously result in the same clinical and radiological outcome as defects treated with guided bone regeneration (GBR). MATERIALS AND METHODS Twenty-two patients who received at least one implant with a small bony dehiscence defect were enrolled in the ...

Biogenic emissions of dimethylsulfide (DMS) are an important source sulfur to the atmosphere, with implications for aerosol formation and cloud albedo over ocean. Natural sources constitute largest uncertainty in estimates radiative forcing climate thus, improved understanding DMS is needed. Coral reefs strong point DMS; however, this coral biogenic not explicitly included climatologies or mode...

ABSTRACT We present a high-resolution seawater radiocarbon (Δ 14 C) record from Porites coral collected Masthead Island in the southern Great Barrier Reef (GBR) covering years 1945–2017. The Δ C values 1945–1953 (pre-bomb era) averaged –49‰. As result of bomb-produced atmosphere, started to rise rapidly 1959, levelled off at ∼131‰ late 1970s and gradually decreased ∼40.3‰ by 2017 due decrease a...

PURPOSE The expression of genes regulated by estrogen in the uterus was studied in ovariectomized (OVX) rats treated with germinated brown rice (GBR) bioactives, and compared to Remifemin or estrogen at different doses to identify the regulation of these genes in the uterus and their molecular mechanisms. METHODS Rats were treated orally with GBR bioactives (phenolics), acylated steryl glucos...

The research focused on Group Based Resiliency (GBR), the perception of ingroup’s ability to positively deal with contextual threats. Based on the uncertainty reduction theory, we advanced that GBR contributes to prevent negative effects of threats to the ingroup. We successfully tested a SEM in which when the ingroup is presented as resilient a contextual threat elicits a stronger perception o...