Existing Global Data Computation (GDC) protocols for asynchronous systems are round-based algorithms designed for fully connected networks. In this paper, we discuss GDC in asynchronous chordal rings, a nonfully connected network. The virtual links approach to solve the consensus problem may be applied to GDC for non-fully connected networks, but it incurs high message overhead. To reduce the o...

AIM This study reports the influence of hypoxia on response of colorectal cancer cells to anticancer effects of sorafenib in combination with PI3K inhibitors GDC-0941 and BEZ-235. MATERIALS AND METHODS All hypoxic exposures were carried out at 1% O2/5% CO2. Antiproliferation activity was evaluated by 48 hours propidium iodide and 14 days clonogenic assay. Protein levels were evaluated by fluo...

As accumulating evidences suggest close involvement of phosphatidylinositol 3-kinase (PI3K) in various diseases particularly cancer, considerable competition occurs in development of PI3K inhibitors. Consequently, novel PI3K inhibitors such as ZSTK474, GDC-0941 and NVP-BEZ235 have been developed. Even though all these inhibitors were reported to inhibit class I PI3K but not dozens of protein ki...

Anaplastic (ATC) and certain follicular thyroid-carcinomas (FTCs) are radioresistant. The Phosphatidylinositide 3-kinase (PI3K) pathway is commonly hyperactivated in thyroid-carcinomas. PI3K can modify the PI3K-related kinases (PIKKs) in response to radiation: How PIKKs interact with PI3K and contribute to radioresistance in thyroid-carcinomas is unknown. Further uncertainties exist in how thes...

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is divided into two major histological subgroups, i.e., embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several clinical trials using HH inhibitors for therapy of RMS have been launched. We here compared the antitumoral effects of the SMO inhibitors GDC-0449, ...

PURPOSE The hedgehog (Hh) signaling pathway, a key regulator of cell growth and differentiation during development is implicated in pathogenesis of certain cancers. Vismodegib (GDC-0449) is a small-molecule inhibitor of smoothened, a key component of Hh signaling. This phase I trial assessed GDC-0449 treatment in patients with solid tumors refractory to current therapies or for which no standar...

BACKGROUND AND PURPOSE Acceleration of intra-aneurysmal clot organization and fibrosis may be a solution to preventing aneurysm recanalization after endovascular treatment. The purpose of this study was to evaluate the short-term efficacy and long-term safety of the new Matrix coil system. METHODS Matrix coils consist of thin platinum coils covered with a bioabsorbable, polymeric material (po...

BACKGROUND AND PURPOSE The purpose of this study was to document the incidence and radiologic appearance of thromboembolic events during Guglielmi detachable coil (GDC) embolization for asymptomatic basilar artery (BA) bifurcation and BA-superior cerebellar artery (SCA) aneurysms by using diffusion-weighted (DW) MR imaging, with special emphasis on the evidence of thromboembolic events in vascu...

Existing Global Data Computation (GDC) protocols for asynchronous systems are designed for fully connected networks. In this paper, we discuss GDC in a dedicated asynchronous chordal ring, a type of un-fully connected networks. The virtual links approach, which constructs t+1 (t<n) process-disjoint paths for each pair of processes without direct connection to tolerate failures (where t is the m...

The generalized dominance computation (GDC) problem is stated as follows: Let A = fa 1 ; a 2 ; : : :; a n g be a set of triplets, i.e. a i = (x i ; y i ; f i), \<" be a linear order relation deened on x-components, \<" be a linear order relation deened on y-components and \" an abelian operator deened on f-components. It is required to compute for every a i 2 A, the expression D(a i) = f j 1 f ...