Background: Metformin is an insulin sensitizing drug, which is co-administered with Clominophene citrate or gonadotropins in most cases of polycystic ovary syndrome (PCOS), to improve ovulation. STK11 gene is necessary for action of metformin. Therefore the study of STK11 polymorphisms is important as pharmacogenetics aspects of metformin. The aim of our study was to investigate polymorphism of...

; Plants respond to various abiotic stimuli by activation and propagation of fast electrical signals, action potentials. To resolve the temporal increase in cytosolic Ca during the action potentials of higher plants, we regenerated transgenic potato plants that expressed the Ca photoprotein apoaequorin. These genetically engineered potato plants were used for simultaneous measurements of transi...

this experiment was conducted to determine gene action for different traits of chickpea including days to 50% flowering, days to maturity, plant height, 100-seed weight, number of primary branches, and number of pods per plant and seed yield since 2006 to 2009 in sararood dry land research sub institute in kermanshah. five genotypes arman, hashem, ilc588, iccv2 and ilc3279 were selected and cro...

Breeding maize for drought tolerance necessitates the knowledge on tolerant genotypes, molecular basis of drought tolerance mechanism, action, and expression pattern of genes. Studying the expression pattern and gene action of candidate genes during drought stress in the hybrids will help in choosing target genes for drought tolerance breeding. In the present investigation, a set of five hybrid...

objective: adipocyte and skeletal muscle are important tissues which contribute the development and progression of metabolic disorder. insulin has a major regulatory function on glucose metabolism in these tissues by redistributing glucose transporter (glut4) from intracellular vesicles to the cell surface. today, due to the side effects of chemical medications attendance to herbal medicines is...

soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. however, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 mapk) as the main therapeutic targets were...

the inheritance of cold resistance was evaluated at the germination stage in crosses between seven rice genotypes as half diallel. analysis of variance indicated that there were highly significant differences among the genotypes, general combining ability (gca) and specific combining ability (sca) for percentage of reduction in radicle length (rl), percentage of reduction in plumule length (pl)...