Vertebrates require tremendous molecular diversity to defend against numerous small hydrophobic chemicals. UDP-glucuronosyltransferases (UGTs) are a large family of detoxification enzymes that glucuronidate xenobiotics and endobiotics, facilitating their excretion from the body. The UGT1 gene cluster contains a tandem array of variable first exons, each preceded by a specific promoter, and a co...

Rice production has been significantly hindered by frequent drought events in recent times, directly impacting food security and agricultural sustainability. In the current study, a set of 100 diverse rice accessions from 3K RG panel were evaluated for Epidermal patterning factor 2 (OsEPF2) loci which governs stomatal density on matured leaves preventing excessive development. This plays an imp...

Brown Planthopper is one of the economically important rice pests that cause several crop failures in Asian countries. Unfortunately, could migrate to neighboring countries generate interpopulation breeding, thus further increasing gene flow and spreading insecticide resistance. This research aimed understand genetic differentiation among all populations. study used two COI sequences from Malan...

Haplotypes represent underlying polymorphisms more than single SNPs, and are considered as a more informative format of data in association analysis. To model haplotypes, it requires high degrees of freedom, which could decrease power and limit a model’s capacity to incorporate other complex effects such as interactions. Even within haplotype blocks, high degrees of freedom are still a concern ...

Idiopathic Parkinson's disease is a common movement disorder characterized by a loss of dopaminergic neurons in the substantia nigra. Its pathogenesis is postulated to involve complex interactions between genetic susceptibility and environmental exposures. The IGF2-INS-TH gene cluster on the telomeric end of human chromosome 11 is a gene rich region expressing several proteins important for dop...

The distribution of β-globin gene haplotypes was studied in 209 Amerindians from eight tribes of the Brazilian Amazon: Asurini from Xingú, Awá-Guajá, Parakanã, Urubú-Kaapór, Zoé, Kayapó (Xikrin from the Bacajá village), Katuena, and Tiriyó. Nine different haplotypes were found, two of which (n. 11 and 13) had not been previously identified in Brazilian indigenous populations. Haplotype 2 (+ -) ...

One of the major interests of current genomics research is disease-gene association, that is, identifying which DNA variation or a set of DNA variations is highly associated with a specific disease. In particular, single nucleotide polymorphisms (SNPs), which are the most common form of DNA variation on the human genome, and a set of SNPs on one chromosome, referred to as a haplotype, are at th...

The present study gives further evidence for the recently found association between variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and PUFA in blood phospholipids and explores this association for cellular fatty acids in erythrocyte membranes. In a subgroup of adults participating in the Bavarian Nutrition Survey II, a cross-sectional population-based...

conclusions polymorphism in the hemochromatosis gene may confer some degree of risk for hcv infection, and individuals carrying the h and c alleles may be susceptible to this disease; however, a larger sample of hcv patients and healthy individuals may be necessary to further illustrate the role of these polymorphisms in hcv. patients and methods hfe gene polymorphisms were examined in a total ...