escherichia coli (e. coli) bacteria can damage dna of the gut lining cells and may encourage the development of colon cancer according to recent reports. genetic switches are specific sequence motifs and many of them are drug targets. it is interesting to know motifs and their location in sequences. at the present study, gibbs sampler algorithm was used in order to predict and find functional m...

background and purpose: mycotoxins are secondary fungal metabolites with a very high diversity that are produced by some species of aspergillus which frequently leads to contaminate food and agricultural products. recently, elimination of aflatoxin contamination in food and feed has been considered by scientists worldwide. although, the antibacterial and antifungal effects of vitamins as natura...

objective: it has been suggested that low frequency stimulation (lfs) exerts its inhibitory effect on epileptogenesis through adenosine receptors activation. in the present study, effect of different lfs frequencies on a1 and a2a receptors gene expression was investigated in perforant path kindled seizures. materials and methods: animals were kindled by perforant path stimulation. afterdischarg...

efg1 transcription factor is believed to be the main regulator of hyphal formation under many different conditions. in addition, it is responsible for positive regulation of the expression of several hyphal-specific genes. sap5, which encodes secreted aspartic proteinase, is one of the mentioned genes and is crucial for pathogenicity properties. in the present work we have established the exper...

objective: micro-rnas (mirnas) are a class of posttranscriptional regulators that play crucial roles in various biological processes. emerging evidence suggests a direct link between mirnas and development of several diseases including type 2 diabetes (t2d). in this study, we aimed to investigate the effect of predicted mirna and target genes on insulin resistance. materials and methods: this e...

Background and Aims: Myeloid cell leukemia-1 (Mcl-1) plays a pivotal role in the survival of hematologic and solid tumors, and is known as a substantial oncogene. Studies have demonstrated the altered expression of Mcl-1 has been linked to malignancy development and poor prognosis. In this research, we have studied the expression of Mcl-1 mRNA in myelodysplastic syndrome (MDS) patients and det...

Non-steroidal anti-inflammatory drugs (NSAIDs) identified effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein-protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO dat...

Background: The potential of plants, as a safe and eukaryotic system, is considered in the production of recombinant therapeutic human protein today; but the expression level of heterologous proteins is limited by the post-transcriptional gene silencing (PTGS) response in this new technology. The use of viral suppressors of gene silencing can prevent PTGS and improve transient expression level ...