Quantitative structure-activity relationships (QSAR) were developed to predict the inhibition ratio of pyrrolidine derivatives on matrix metalloproteinase via heuristic method (HM) and gene expression programming (GEP). The descriptors of 33 pyrrolidine derivatives were calculated by the software CODESSA, which can calculate quantum chemical, topological, geometrical, constitutional, and electr...

We established a novel method, Gene Expression Profiling via Multigene Concatemers (MgC-GEP), to study multigene expression patterns simultaneously. This method consists of the following steps: (1) cDNA was obtained using specific reverse primers containing an adaptor. (2) During the initial 1-3 cycles of polymerase chain reaction (PCR), the products containing universal adaptors with digestion...

Climate change and its adverse environmental impacts are major concerns for Small Island Developing States (SIDS), such as Saint Lucia. In particular, the annual atmospheric temperature rainfall continue to receive a great deal of attention in Caribbean worldwide. Subsequently, looking at spatiotemporal elements meteorological factors with regard evolving environment, especially countries where...

PURPOSE OF REVIEW This review deals with the emerging promises of gene expression profiling (GEP) and the currently accumulating knowledge about the classification and the discovery of novel disease entities in clinical acute myeloid leukemia (AML). RECENT FINDINGS Gene expression profiling studies in AML have shown that known and novel classes of disease can be recognized by unsupervised ana...

An accurate prediction of pipes failure rate plays a substantial role in the management Water Distribution Networks (WDNs). In this study, field study was conducted to register break and relevant causes WDN Yazd City, Iran. way, 851 water were incepted localized by Global Positioning System (GPS) apparatus. Then, 1033 cases reported eight zones understudy during March-December 2014. Pipes (BRP)...

BACKGROUND Most biological samples are cell mixtures. Some basic questions are still unanswered about analyzing these heterogeneous samples using gene expression microarray technology (MAT). How meaningful is a cell mixture's overall gene expression profile (GEP)? Is it necessary to purify the cells of interest before microarray analysis, and how much purity is needed? How much does the purific...

AIMS A non-invasive gene-expression profiling (GEP) test for rejection surveillance of heart transplant recipients originated in the USA. A European-based study, Cardiac Allograft Rejection Gene Expression Observational II Study (CARGO II), was conducted to further clinically validate the GEP test performance. METHODS AND RESULTS Blood samples for GEP testing (AlloMap(®), CareDx, Brisbane, CA...

The stimulation effect of oil wells is seriously affected by the complexity hydraulic fractures, and analysis factors that control fracture index has become key to fracturing design in sandy conglomerate reservoirs. Based on intrinsic relationship between geological engineering parameters fractures index, a Genetic Expression Programming (GEP) method, which broad advantages solving multi-factor...

Gene expression profiling (GEP) had divided the diffuse large B-cell lymphoma (DLBCL) into molecular subgroups: germinal center B-cell like (GCB), activated B-cell like (ABC), and unclassified (UC) subtype. However, this classification with prognostic significance was not applied into clinical practice since there were more than 1000 genes to detect and interpreting was difficult. To classify c...

Gene regulatory networks inference is currently a topic under heavy research in the systems biology field. In this paper, gene regulatory networks are inferred via evolutionary model based on time-series microarray data. A non-linear differential equation model is adopted. Gene expression programming (GEP) is applied to identify the structure of the model and least mean square (LMS) is used to ...