نتایج جستجو برای: gene expression signature

تعداد نتایج: 1655967  

2010
Claas H Hinze Ndate Fall Sherry Thornton Jun Q Mo Bruce J Aronow Gerlinde Layh-Schmitt Thomas A Griffin Susan D Thompson Robert A Colbert David N Glass Michael G Barnes Alexei A Grom

INTRODUCTION Previous observations suggest that active systemic juvenile idiopathic arthritis (sJIA) is associated with a prominent erythropoiesis gene-expression signature. The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions. METHODS The 199 patie...

Journal: :physiology and pharmacology 0
saeed esmaeili-mahani department of biology, faculty of sciences, shahid bahonar university of kerman, kerman, iran zahra hajializadeh laboratory of molecular neuroscience, kerman neuroscience research center, kerman university of medical sciences, kerman, iran shima torkzadeh-mahani laboratory of molecular neuroscience, kerman neuroscience research center, kerman university of medical sciences, kerman, iran

introduction: g-proteins have an important role in the cell signaling of numerous receptors. the situation of g-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. here, the changes in the expression of g-protein subunits (gαi, gαs and gβ) were evaluated in hyperglycemic situation of pc12 cells as a cellular model...

Journal: :iranian journal of public health 0
a hossein-nezhad national institute of genetic engineering and bio technology, tehran, iran gh ahangari national institute of genetic engineering and bio technology, tehran, iran b larijani endocrinology and metabolism research center, tehran university of medical sciences, iran

background: to evaluate vdr gene variation and its interaction with immune regulatory molecules in osteoporosis. methods: totally 205 pre and postmenopausal women were recruited in the study. after an overnight fast, peripheral blood was taken and centrifuged to sprat serum for measurement of serum parathyroid hormone, 25 hydroxyvitamin d, osteocal­cin and cross laps. the fok i polymorphism in ...

Journal: :iranian journal of allergy, asthma and immunology 0
leila mohammadi amirabad department of medical genetics, national institute of genetic engineering and biotechnology, tehran, iran ghasem ahangari department of medical genetics, national institute of genetic engineering and biotechnology, tehran, iran gholamreza derakhshan deilami department of lung diseases, imam khomeini hospital, tehran university of medical sciences, tehran, iran

asthma is a chronic inflammatory disorder of the airways. the stress is a factor for asthma which indicates a disorder in the function of communicational mediators of nervous and  immunological systems  such  as  neurotransmitters.  a  study  indicated  that  blood serotonin concentration increases in asthmatic patients. other study indicates that one kind of the serotonin  receptors, named 5ht...

Journal: :journal of paramedical sciences 0
hamid alavi majd biostatistics department, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran soodeh shahsavari biostatistics department, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran soheila khodakarim school of public health, shahid beheshti university of medical science, tehran seyyed mohammad tabatabaei medical informatics department, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran bi bi fatemeh nobakht motlagh ghochani proteomics research center, shahid beheshti university of medical sciences, tehran

an important step in considering of gene expression data is obtained groups of genes that have similarity patterns. biclustering methods was recently introduced for discovering subsets of genes that have coherent values across a subset of conditions. the las algorithm relies on a heuristic randomized search to find biclusters. in this paper, we introduce biclustering las algorithm and then appl...

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