Non-steroidal anti-inflammatory drugs (NSAIDs) identified effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein-protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO dat...

Abstract_ Introduction: Viola plant has been used traditionally for the treatment of neurological disorders. We aimed at determining whether pretreatment with Viola spathulata extract can alleviate the severity of ischemic-reperfusion damages and it can exert its protective effects through the regulation of a sodium/calcium exchanger (NCX3) gene expression in a rat brain. Methods: Male Wistar r...

15 ABSTRACT Motivation: Inferring gene-regulatory networks is very crucial in decoding various complex mechanisms in biological systems. Synthesis of a fully functional transcriptional factor/protein from DNA involves series of reactions, leading to a delay in gene regulation. The 20 complexity increases with the dynamic delay induced by other small molecules involved in gene regulation, and no...

Abstract Background Clear cell renal carcinoma (ccRCC), derived from tubular epithelial cells, is the most common malignant tumor of kidney. The study key genes related to pathogenesis ccRCC has become important for gene target therapy. Methods Bioinformatics analysis Cancer Genome Atlas (TCGA), NCBI Gene Expression Omnibus (GEO) database, USUC Xena cBioPortal Genomics, and MethSurv were perfor...

background: herbal medicine is a new complementary strategy for treating diseases such as cancer. however, its mechanism of action is not clear yet. this study investigates antitumor efficacy of polygonum avicular extract on mcf-7 cell line . methods: mcf-7 cells were treated with different concentrations of (50, 100, 150, 200, 250, 300,350 400 ng/âµl) polygonum avicular at different time inter...

objective(s):eukaryotic translation initiation factor 4e (eif4e) is overexpressed in cervical cancer (cc). however, the molecular mechanisms are unclear. this study aimed to investigate the molecular mechanism of eif4e gene overexpression in cc. materials andmethods:the human papillomavirus (hpv) type 18 e7 and eif4e mrnas were measured following knock down or overexpression of e7 gene by rt-pc...

Cancer is a disease regulated by the underlying gene networks. The emergence of normal and cancer states as well as the transformation between them can be thought of as a result of the gene network interactions and associated changes. We developed a global potential landscape and path framework to quantify cancer and associated processes. We constructed a cancer gene regulatory network based on...

Cellular processes are the interaction of multiple proteins, genomic sites, RNAs, small molecules, and their complexes. The set of these interactions and their contexts provide biological understanding of functionality beyond single-gene annotation. Biological networks have emerged as the dominant method of communicating, modeling, and understanding cellular processes and pathways. Computationa...

In this work, we reconstruct the gene regulation networks from the microarray experiments data by Bayesian networks approach. We use the evolutionary algorithm for the search-and-score based structure learning methods. The learned network is tested by the hypothesis testing with two populations of patient data, one with treatment (drugs), other without treatment. The answer of question ”How doe...