OBJECTIVE To assess whether patients receiving opioid substitution therapy (OST) in general practice cause other patients sufficient distress to change practices--a perceived barrier that prevents general practitioners from prescribing OST. DESIGN, SETTING AND PARTICIPANTS A cross-sectional questionnaire-based survey of consecutive adult patients in the waiting rooms of a network of research ...

The toxicity of stormwater runoff during various time-based stages was measured in both grab and composite samples collected from three highly urbanized highway sites in Los Angeles, California between 2002 and 2005. Stormwater runoff samples were tested for toxicity using three freshwater species (the water flea Ceriodaphnia dubia, the fathead minnow Pimephales promelas, and the green algae Ps...

Objective: to evaluate and correlate the quality of life financial toxicity adult patients undergoing hematopoietic stem cell transplantation during COVID-19 pandemic. Method: observational, analytical study, carried out with 35 in a reference hospital for Latin America. For data collection, Functional Assessment Cancer Therapy Bone Marrow Transplantation COmprehensive Score Financial Toxicity ...

Salicylate, the active component of the common drug aspirin, has mild analgesic, antipyretic, and anti-inflammatory effects at moderate doses. At higher doses, however, salicylate temporarily induces moderate hearing loss and the perception of a high-pitch ringing in humans and animals. This phantom perception of sound known as tinnitus is qualitatively similar to the persistent subjective tinn...

Therapeutic Deep Eutectic Systems (THEDESs) are a mixture of components, including an active pharmaceutical ingredient, that have recently emerged because their interesting properties for drug therapies. In general, they been recognized to increase the solubility and permeability some drugs, consequently, bioavailability. Moreover, also used novel formulations pharmaceuticals. Despite potential...

Contemporary information on road salt runoff is needed for management of water resources in regions experiencing urbanization and increased road density. We investigated seasonal Cl(-) concentrations among five streams in south-central Indiana that drained watersheds varying in degree of urbanization and ranging in size from 9.3 to 27 km(2). We also conducted acute toxicity tests with Daphnia p...

Sediment toxicity tests are valuable tools for assessing the potential effects of contaminated sediments in dredged material evaluations because they inherently address complexity (e.g., unknown contaminants, mixtures, bioavailability). Although there is a need to understand the chronic and sublethal impacts of contaminants, it is common to conduct only short-term lethality tests in evaluations...

Background: Carissa edulis is widely used in traditional medicine to manage numerous ailments. However, few studies have assessed its toxicity. Therefore, this study aimed determine acute and sub-toxicity levels of C. methanol extract. Methods: In the toxicity probe, a limit test was conducted whereby extract given as solo dose by gavage. The rats were observed for two weeks. observations inclu...

Introduction : The G8 Score is an important tool for geriatric assessment in current oncology practice. applied as a prescreening method selection of patients who need comprehensive (CGA); however, this questionnaire has not been validated Russia. Study goal To evaluate the reliability and predictive role Russian version evaluating risk complications systemic antitumor therapy elderly patients....

Predicting toxicity quantitatively, using Quantitative Structure Activity Relationships (QSAR), has matured over recent years to the point that the predictions can be used to help identify missing comparison values in a substance's database. In this manuscript we investigate using the lethal dose that kills fifty percent of a test population (LD₅₀) for determining relative toxicity of a number ...