Research on nanoparticles has created interest among the biomedical scientists. Nanoparticle conjugation aims to target drug delivery, increase drug efficacy and imaging for better diagnosis. Toxicity profile of the nanoconjugated molecules has not been studied well. In this communication, the toxicity profile of snake venom cytotoxin (NKCT1), an antileukemic protein toxin, was evaluated after ...

in this paper, a new approach was presented for bus network design which took the effects of three out of four stages of the bus planning process into account. the presented model consisted of three majors steps 1- network design procedure (ndp), 2- frequency determination and assignment procedure (fdap), and 3- network evaluation procedure (nep). genetic algorithm (ga) was utilized to solve th...

In applications of HTN planning, repeated problems have arisen from the lack of correspondence between HTN tasks and classical-planning goals. We describe these problems and provide a new Hierarchical Goal Network (HGN) planning formalism that overcomes them. HGN tasks have syntax and semantics analogous to classical planning problems, and this has several benefits: HGN methods can be significa...

A feeding network crossing method is proposed to form an N $\times $ dual-polarized two-dimensional multibeam antenna array (2D-MBAA) with analog-digital hybrid beamforming, which solves the problem of needing additional connection structure between and analog for large-scale arrays. The main design work focused on analog-beamformer (ABF) two structures are proposed. One vertical-crossed (VC) A...

Melanomas are fast growing high-mortality tumors, and specific treatments for melanomas are needed. Melanoma cells overexpress focal adhesion kinase (FAK) compared to normal keratinocytes, and we sought to exploit this difference to create a selectively lethal therapy. We combined gold nanoparticles (GNP) with antibodies targeting phosphorylated FAK (p-FAK). These conjugates (p-FAK-GNP) entered...

Financial networks have been extensively studied as examples of real world complex networks. In this paper, we establish and study the network of venture capital (VC) firms in China. We compute and analyze the statistical properties of the network, including parameters such as degrees, mean lengths of the shortest paths, clustering coefficient and robustness. We further study the topology of th...

We examined the genetic requirements for the Myc family of oncogenes in normal Sonic hedgehog (Shh)-mediated cerebellar granule neuronal precursor (GNP) expansion and in Shh pathway-induced medulloblastoma formation. In GNP-enriched cultures derived from N-myc(Fl/Fl) and c-myc(Fl/Fl) mice, disruption of N-myc, but not c-myc, inhibited the proliferative response to Shh. Conditional deletion of c...

Proteins are major effectors of biological functions, and differentially expressed proteins (DEPs) are widely reported as biomarkers in pathological mechanism, prognosis prediction as well as treatment targeting in cancer research. High-throughput technology of mass spectrometry (MS) has identified large amounts of DEPs in human cancers. Through mining published researches with detailed experim...

One approach to improving the generalization power of a neural net is to try to minimize the number of non-zero weights used. We examine two issues relevant to this approach, for single-layer nets. First we bound the VC dimension of the set of linearthreshold functions that have non-zero weights for at most s of n inputs. Second, we show that the problem of minimizing the number of non-zero inp...