2 Abbreviations AC adenylyl cyclase ATD amino-terminal domain cNMP cyclic nucleotide monophosphate dpa D-phenylalanine taste sensitivity locus G protein guanine nucleotide binding regulatory protein GPCR G protein coupled receptor IP 3 inositol trisphosphate NCBI National Center for Biotechnology Information PDE phosphodiesterase PLC phospholipase C PROP 6-n-propyl-2-thiouracil sac saccharin ta...

The people have different behaviour to choose the food, and there are many factors that affect the food choices. The best significant factor to choose the food is taste. Differences in taste perception of several taste modalities are associated to difference in the taste receptors. Polymorphisms of the genes that encoding these taste receptors may clarify this unpredictability in taste percepti...

BACKGROUND AND OBJECTIVES Although there are many studies on the umami receptor and its signaling pathway, literature on the effect of umami taste acuity on dietary choices in healthy subjects is limited. The current study aims to clarify the relationship between umami taste acuity with sweet or bitter taste acuity, food preference and intake. METHODS AND STUDY DESIGN Forty-two healthy Japane...

Given the increasing evidence that supports the ability of humans to taste non-esterified fatty acids (NEFA), recent studies have sought to determine if relationships exist between oral sensitivity to NEFA (measured as thresholds), food intake and obesity. Published findings suggest there is either no association or an inverse association. A systematic review and meta-analysis was conducted to ...

Taste learning, and particularly conditioned taste aversion (CTA), is an adaptive learning involving complex brain mechanisms and molecular pathways. Taste learning and CTA are critical behaviors for survival, and the knowledge of the molecular bases involved in the acquisition, retention and extinction of CTA can help to understand the brain mechanisms of normal and altered taste learning. The...

BACKGROUND The TAS2R38 gene is widely responsible for the well-known bimodal response to a family of bitter chemicals which includes 6-n-propylthiouracial (PROP). There are two common haplotypes of this gene, the recessive AVI and the dominant PAV, both of which are well studied. Conversely, the role of rare TAS2R38 haplotypes on bitter taste sensitivity has been notoriously difficult to study ...

In the daily language the word " taste " refers to the sensations that professionals carefully distinguish as taste and odour, or flavour. The sense of taste is notably robust with age, whereas declines in the sense of olfaction are dramatic. Age-related changes in taste functioning do not affect all individuals, and some elderly individuals are essentially unimpaired. Age has a more significan...

Carbonated beverages are commonly available and immensely popular, but little is known about the cellular and molecular mechanisms underlying the perception of carbonation in the mouth. In mammals, carbonation elicits both somatosensory and chemosensory responses, including activation of taste neurons. We have identified the cellular and molecular substrates for the taste of carbonation. By tar...