Endometriosis is a relatively common condition in women of reproductive age and is associated with considerable morbidity. Despite an extensive literature describing its multiple clinical manifestations, their management, and many aspects of the biology of endometriotic lesions, the pathophysiological mechanisms involved remain poorly understood. A genetic component in endometriosis is now reco...

In our view, gene therapy may ameliorate some human genetic diseases in the future. For this reason, we believe that research directed at the development of techniques for gene therapy should continue. For the foreseeable future, however, we oppose any further attempts at gene therapy in human patients because (i) our understanding of such basic processes as gene regulation and genetic recombin...

text. For example, microfilaments are incorrectly introduced as being “~35 nm in diameter,” but the same chapter subsection also provides the correct relative diameters of microtubules and intermediate filaments. Perhaps subsequent editions of the textbook will address these issues. The strength of the textbook lies in its ability to promote active learning by applying acquired physiological kn...

The discovery that RNA can act as a biological catalyst, as well as a genetic molecule, indicated that there was a time when biological reactions were catalysed in the absence of protein-based enzymes. It also provided the platform to develop those catalytic RNA molecules, called ribozymes, as trans -acting tools for RNA manipulation. Viral diseases or diseases due to genetic lesions could be t...

The clinical presentation of asthma and intensity airway inflammation presents with heterogeneity. Asthma management aims to minimize the symptom s risk exacerbations achieve control over disease. Risk factors include smoking, obesity, occupational environmental factors, a genetic predisposition, among others. therapy disease . Pharmacological treatment is based