Recent evidence suggests that many complex diseases are caused by genetic variations that play regulatory roles in controlling gene expression. Most genetic studies focus on nonsynonymous variations that can alter the amino acid composition of a protein and are therefore believed to have the highest impact on phenotype. Synonymous variations, however, can also play important roles in disease pa...

Genetic constitution represents an important cause for individual variations in the response and tolerance to drug treatment. Th ese variations are due to the germline mutations in genes that encode for drug-metabolizing enzymes, transporters, cellular targets and signaling pathways. Th e identifi cation of genetic variations that predict for drug response is an important step towards the trans...

Rare, high-penetrance genetic variations account for a small portion of genetic cancer syndromes. In contrast, most cancers develop from a combination of minor genetic influences and environmental factors. There are numerous publications on cancer susceptibility. In contrast, genetic studies in treatment response and outcome analyses are a rapidly emerging field. Approaches used in disease susc...

PURPOSE Mitochondria and ionizing radiation overlap in a number of features; for instance, both generate harmful reactive oxygen species, and that radiation can induce cell death through the intermediary of mitochondria. Because a number of genetic variations in nuclear genes are frequently associated with response to cancer treatment, the aim of this case-control study was to test the hypothes...

to evaluate the genetic variations in eleven fennel populations in iran, 55 accessions were analyzed by srap markers. twelve primer combinations produced 171 polymorphic bands. the cumulative dendrogram delineated fennel accessions into five major groups in accordance to the geographical regions from which the populations were originated. about 43.57% of total genetic variation was detected amo...

abstract in this study, two wild iranian crocus species (crocus speciosus and crocus cancellathus) were examined using 16 morphological characters and 13 issr primers on 250 and 25 plant samples, respectively. the highest and lowest coefficient of variations were belonged to the thickness of the petals (71.25%) and the leaf length (15.08%), respectively. cluster analysis based on morphological ...

Stargardt disease (STGD) is an inherited genetic eye condition involving bilateral macular dystrophy leading to progressive central vision loss. It is the most common form of autosomal recessive juvenile macular dystrophy. In this study, ELOVL4 and PRPH2 genes were analyzed in 30 STGD probands for genetic variations using next-generation sequencing. In the patient group, two genetic variants in...

in this study, a total of 101,147 monthly test day records of somatic cell count collected from 13,977 first lactation holstein cows (in 183 herds) calved between 2002 and 2006 were used. for the genetic analysis, a random regression test day model was utilized. somatic cell score (scs) was calculated based on natural logarithm of somatic cell count. in the model, fixed effect of contemporary g...

iran is a part of the secondary centre of origin of melons, and therefore, there is a wealth of genetic variation of these species in this country. the amplified fragment length polymorphism (aflp) marker was applied to investigate the genetic variations among five major iranian melon cultigens (cucumis melo) and ‘ananasi’ as a general well-known cultivar. ten primer pairs were used on 90 indiv...