The increasing amount of available high-content data in genomics, proteomics, and metabolomics has significantly improved the predictive power model accuracy genome-scale metabolic network models recent years. We review constraint-based modeling approaches that incorporate genomics proteomics to form resource allocation models. Different build related enzyme-constrained are discussed evaluated ...

Advances in protein structure determination, led by the structural genomics initiatives have increased the proportion of novel folds deposited in the Protein Data Bank. However, these structures are often not accompanied by functional annotations with experimental confirmation. In this review, we reassess the meaning of structural novelty and examine its relevance to the complexity of the struc...