نتایج جستجو برای: genotype imputation
تعداد نتایج: 107592 فیلتر نتایج به سال:
Imputation of moderate-density genotypes from low-density panels is of increasing interest in genomic selection, because it can markedly reduce genotyping costs. Several imputation software packages have been developed; however, these vary in imputation accuracy and imputed genotypes may be inconsistent over methods. An AdaBoost-like approach was developed to combine imputation results from sev...
MOTIVATION Genotype imputation has become an indispensible step in genome-wide association studies (GWAS). Imputation accuracy, directly influencing downstream analysis, has shown to be improved using re-sequencing-based reference panels; however, this comes at the cost of high computational burden due to the huge number of potentially imputable markers (tens of millions) discovered through seq...
Imputation is a powerful in silico approach to fill in those missing values in the big datasets. This process requires a reference panel, which is a collection of big data from which the missing information can be extracted and imputed. Haplotype imputation requires ethnicity-matched references; a mismatched reference panel will significantly reduce the quality of imputation. However, currently...
MOTIVATION In modern sequencing studies, one can improve the confidence of genotype calls by phasing haplotypes using information from an external reference panel of fully typed unrelated individuals. However, the computational demands are so high that they prohibit researchers with limited computational resources from haplotyping large-scale sequence data. RESULTS Our graphics processing uni...
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