Conservation of genetic resources by semen cryopreservation is essential for biodiversity conservation and storage rare poultry breeds. Despite the widespread use this method not all individuals presentia similar capacity to be used after defrosting. The aim current study was identify SNP markers linked candidate genes potentially associated with rooster (Gallus gallus) sperm motility cryoprese...

Clinical nephrology has advanced rapidly due to recent breakthroughs in genomic medicine. Several forms of nephropathy heretofore labeled “idiopathic” now have a well-defined genetic basis; more will follow. Whereas it was once taboo to suggest that population ancestry-based genetic variation contributes to ethnic-specific risk for end-stage kidney disease (ESKD), the identification of impressi...

objective(s):to the best of our knowledge, this is the first report on the contributions of gst genetic variants to the risk of diabetic retinopathy in an iranian population. therefore, the objective of this study was to determine whether sequence variation in glutathione s-transferase gene (gstm1 and gstt1) is associated with development of diabetic retinopathy in type 2 diabetes mellitus (t2d...

Huntington disease (HD) is a progressive neurodegenerative disorder with autosomal dominant inheritance, characterized by choreiform movements and cognitive impairment. Onset of symptoms is around 40 years of age and progression to death occurs in approximately 10 to 15 years from the time of disease onset. HD is associated with an unstable CAG repeat expansion at the 5' and of the IT15 gene. W...

Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors. Here, we make use of extensive phenotype data in Iceland, long-range phased genotypes, and a population-wide genealogical database to examine the heritability of 11 quantitative and...

We analyse interactions of Quantitative Trait Loci (QTL) in heat selected yeast by comparing them to an unselected pool of random individuals. Here we reexamine data on individual F12 progeny selected for heat tolerance, which have been genotyped at 25 locations identified by sequencing a selected pool [Parts, L., Cubillos, F. A., Warringer, J., Jain, K., Salinas, F., Bumpstead, S. J., Molin, M...

Abstract Background Meiotic recombination results in the exchange of genetic material between homologous chromosomes. Recombination rate varies different parts genome, individuals, and is influenced by genetics. In this paper, we assessed variation along genome individuals pig using multilocus iterative peeling on 150,000 across nine genotyped pedigrees. We used these data to estimate heritabil...

background ability of athletes in speed or endurance contests somehow is determined by inherited muscle fiber types. one of the important genes involved in sport genetics is actn3 that is located on chromosome 11q13-q14 and encodes α-actinin-3, which belongs to highly conserved family of α-actinin proteins. genetic analysis of α-actinin-3 gene has showed a polymorphism r577x (rs1815739), which ...

BACKGROUND Mutations in ATP-binding-cassette-member A3 (ABCA3) are related to severe chronic lung disease in neonates and children, but frequency of chronic lung disease due to ABCA3 mutations in the general population is unknown. We tested the hypothesis that individuals heterozygous for ABCA3 mutations have reduced lung function and increased risk of COPD in the general population. METHODS ...