Gestational diabetes mellitus, broadly defined as carbohydrate intolerance beginning or first recognized during pregnancy, 1,2 was originally described decades ago and has since been the subject of extensive research. Yet the most recent guidelines of the U.S. Preventive Services Task Force, noting the absence of data to establish a clear link between screening and improved outcomes of affected...

background: gestational diabetes mellitus (gdm) is a common obstetrical complication with both maternal and fetal side effects.objective: this study was performed to determine the complications in neonates of mothers with gdm receiving insulin vs. dietary regimen.materials and methods: in this prospective cohort study, 140 neonates of mothers with gdm attending javaheri hospital of azad univers...

Insulin resistance during pregnancy provokes gestational diabetes mellitus (GDM); however, the cellular mechanisms for this type of insulin resistance are not well understood. We evaluated the mechanisms(s) for insulin resistance in skeletal muscle from an animal model of spontaneous GDM, the heterozygous C57BL/KsJ-(db/+) mouse. Pregnancy triggered a novel functional redistribution of the insul...

OBJECTIVE Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. STUDY DESIGN Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression. RESULTS High maternal BMI (OR = 1.53 (1.11, 2.12)), height (1.98 (1....

 Gestational diabetes mellitus (GDM) is associated with elevated risk of severe perinatal complications and developing type 2 diabetes (T2DM) for both mothers and offspring, and screening and intervention are recognized as an effective way to reduce these risks[1].  The incidence of GDM was 17.5% by a 2013 cohort study of 17186 pregnant women in China[2].  GDM screening and intervention were...

Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism at the interface of fat and carbohydrate metabolism. We report a male patient with GKD and a novel insertion of TT in exon 5 at position 378 of the GK cDNA (378-379insTT). This resulted in a premature stop codon and 0.8% normal GK activity. The mother is a carrier for this mutation and had gestational diabetes requiring ...

Women diagnosed with gestational diabetes mellitus have an increased risk of developing diabetes mellitus, which is a known risk factor for cardiovascular disease and insulin resistance. In the recently published article by Zajdenverg et al., they aimed to identify endothelial dysfunction and cardiovascular risk factors in women with previous gestational diabetes mellitus. However, authors did ...

Abstract Objective: Gestational diabetes mellitus (GDM) is characterized by glucose intolerance during pregnancy. Incidence of gestational diabetes can increase by several factors such as obesity, aging, diet and genetic factors. This study aimed to assess the role of nutrition, biochemical and demographic factors in development of GDM in pregnant women. Materials and Methods: In this prospe...

OBJECTIVE Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin ...

OBJECTIVE Children born small for gestational age (SGA) are at risk for developing type 2 diabetes. Lipodystrophy leads to early type 2 diabetes and leptin reverses the metabolic consequences of the disease. Low IGF-binding protein 1 (IGFBP1) can predict the development of type 2 diabetes. The aim of this study was to determine leptin, insulin, and IGFBP1 in children and adult women born preter...