HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocarcinoma. The aim of the study is to investigate the expression of HtrA1 in thes...

Gestational trophoblastic disease (GTD) is a spectrum of cellular proliferations arising from the placental villous trophoblasts encompassing four main clinicopathologic forms : hydatidiform mole (complete and partial), invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT). Placental site trophoblasic tumours (PSTT) are rare and usually diagnosed after dilatation and cure...

References 1 UK Medical Eligibility Criteria for Contraceptive Use (UKMEC 2009). 2009. http://www.fsrh.org/admin/ uploads/UKMEC2009.pdf [Accessed 10 February 2010]. 2 UK Medical Eligibility Criteria for Contraceptive Use (UKMEC 2005/2006). 2006. http://www.fsrh.org/ admin /up loads /a rch ive /UKMEC2005_06.pd f [Accessed 10 February 2010]. 3 Gaffield ME, Kapp N, Curtis KM. COC and IUD use among...

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2012 there were twelve themed workshops, five of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of clinical research and pregnancy disorders: 1) trophoblast deportation; 2) gestational ...

BACKGROUND The aim of the study was to record the incidence of treatment for infertility prior to development of gestational trophoblastic disease (GTD). METHODS AND RESULTS A retrospective analysis was undertaken of 231 consecutive women receiving chemotherapy for persistent GTD at Weston Park Hospital, Sheffield, from 1991 to 2001. Three patients in this group had received treatment for inf...