Reactive stromal changes in prostate cancer (PCa) are likely involved in the emergence of castration-resistant PCa (CRPC). This study was designed to investigate stromal changes in patients with clinically advanced PCa and analyze their prognostic significance. Prostate needle biopsies obtained from 148 patients before castration therapy were analyzed by Masson trichrome staining and immunohist...

Most men with prostate cancer will not die from it. Although the most frequent cancer in men in the western world it ranks only 3rd place for cause of death (1). In men over 60 years of age prostate cancer is found at autopsy in over 60% (2). Overdiagnosis by PSA screening is estimated to be 57% when screened until 75 years of age (3). Considering treatment toxicity, careful selection of men fo...

BACKGROUND Although there is randomized evidence that radical prostatectomy improves survival, there are few data on how benefit varies by baseline risk. OBJECTIVE We aimed to create a statistical model to calculate the decrease in risk of death associated with surgery for an individual patient, using stage, grade, prostate-specific antigen, and age as predictors. DESIGN, SETTING, AND PARTI...

PURPOSE Low concentrations of citrate and high concentrations of choline-containing compounds (ChoCC) are metabolic characteristics observed by magnetic resonance spectroscopy of prostate cancer tissue. The objective was to investigate the gene expression changes underlying these metabolic aberrations to find regulatory genes with potential for targeted therapies. EXPERIMENTAL DESIGN Fresh fr...

Since the Gleason score was developed in 1966 as a histological classification for prostate cancer, it has been widely used clinical practice and evolved over time. The concept of “tertiary pattern” (also known minor pattern) first proposed 2000, since 2005 International Society Urological Pathology conference. prognostic significance tertiary pattern validated various settings whereas its defi...

Purpose: Low concentrations of citrate and high concentrations of choline-containing compounds (ChoCC) are metabolic characteristics observed by magnetic resonance spectroscopy of prostate cancer tissue. The objective was to investigate the gene expression changes underlying these metabolic aberrations to find regulatory genes with potential for targeted therapies. Experimental design: Fresh fr...

background: prostate cancer is one of the most commonly diagnosed cancers in males. tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. objective: to investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. methods: in this study expression of p53 was examined in p...