A male infant with multiple congenital anomalies and psychomotor retardation was found to have a translocation resulting in partial trisomy for the distal part of chromosome 3p. An older sister with similar clinical findings had an identical karyotype. Chromosome studies in the phenotypically normal parents revealed a balanced translocation in the mother involving chromosomes 3, 11, and 18. An ...

I examined the emergence of automatic postural reactions (righting, equilibrium, and protective reactions) in a group of infants with Down syndrome and in a developmentally matched group of nonhandicapped infants. I assessed the relationship of postural reactions to chronological age and to motor milestone development (as measured by the Bayley Scales of Infant Development). The relationship of...

Intestinal infections due to the flagellate, lamblia intestinalis, attracted attention in England in. the early years of the war when the disease first reaclhed this country from the Eastern fronts. Since 1916, with the exception of Clifford Dobell's report(l), hardly any furt-her reference to the disease has been made in English me(lical literature. I can find no clinical study of the infectio...

Negative and positive symptoms were investigated in a sample of 72 young schizophrenic and depressed patients at followup approximately 1 1/2 years after hospital discharge. Flat affect, poverty of speech, and psychomotor retardation were included as negative symptoms, and delusions, hallucinations, and florid thought disorder as positive symptoms. Marked negative symptoms were found to occur i...

BACKGROUND Altered physical activity is an important feature of depression. It is manifested in psychomotor retardation, agitation and withdrawal from engagement in normal activities. Modern devices for activity monitoring (actigraphs) make it possible to monitor physical activity unobtrusively but the validity of actigraphy as an indicator of mood state is uncertain. We carried out a systemati...

Differential mode delay (DMD) modelling and measurements provide a means to characterise the modal structure of graded-index multimode fibres. In order to compute DMD output time pulses, we need to solve the modal propagation coefficients, modal group velocities and modal chromatic dispersion, compute the weighted modal amplitudes which are dependent on the excitation, and construct time pulses...

BACKGROUND Psychomotor retardation (PR) is one of the core features in depression according to DSM V (1), but also aging in itself causes cognitive and psychomotor slowing. This is the first study investigating PR in relation to cognitive functioning and to the concomitant effect of depression and aging in a geriatric population ruling out contending effects of psychotropic medication. METHOD...

In two cases of infantilism of the type of Herter, in one case of achondroplasia, and in one case of cretinism, creatin was constantly present in the urine and was increased in amount when the ingestion of carbohydrates was increased.

The development of a European isolate of Echinococcus multilocularis was compared in cats and dogs at the end of the prepatent period. Echinococcus multilocularis established in all dogs and cats, but worm recovery was significantly greater from dogs than from cats. Overall, worms in cats were not as advanced as those in dogs in terms of development and maturation, but there was no evidence of ...

AIM Heavy metals such as manganese, arsenic and lead can act as neurotoxins. There have been few human studies of neurobehavioral/neurodevelopmental effects of arsenic and manganese on children in the United States. Since 1998, North Carolina has tested all new private wells for manganese, arsenic and lead. This study was conducted to evaluate adverse neurodevelopmental effects (delayed milesto...