The globulin content of the standard solution in the vials is standardized either by a Kjeldahl or a biuret determination. When available Lederle (gamma) globulin diluted 1:200 can be used for this purpose as well. The diluted Lederle standard globulin coagulates on heating and so cannot be used as a sterilized standard. An interesting phenomenon was observed while preparing the sterilized wate...

Ferritin- and fluorescein-conjugated antibody staining has been applied to a study of a mouse plasma cell tumor. The presence of myeloma globulin within cisternae of the endoplasmic reticulum was observed at a stage of the secretory process when the remainder of the cytoplasm was essentially free of labeled globulin. The distribution of ferritin suggested a functional heterogeneity among units ...

To identify the genetic causality of migraine and acute, severe melalgia, we performed a linkage analysis and exome sequencing in a family with four affected individuals. We identified a variant (R21L) in exon 2 of the GC globulin gene, which is involved in the transportation of vitamin D metabolites and acts as a chemotaxic factor; this variant was co-segregated within the family. To investiga...

Many sera from normal individuals as well as patients with various disease states contain agglutinating antibodies which show specificity for antigenic determinants of gamma-globulin revealed by pepsin digestion at pH 4.1. Sera containing such agglutinating activity as well as sera negative for these agglutinators contain low molecular weight (3S-5S) components of slow gamma-mobility which inhi...

Aleutian disease-affected mink, which are markedly hypergammaglobulinemic, show a decreased half-life of the serum gamma globulin indicating that the hyperglobulinemia is due to increased production. No evidence that the gamma globulin was antibody to the infectious agent, to autologous or isologous tissues, or to antigens the animal was responding to prior to development of the disease was obt...

ELEVATION of the y-globulin concentration in cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and other neurologic disorders has been reported (1-3). Expression of the y-globulin values in milligrams per hundred milliliters does not reveal whether this increase is due to a general elevation of total protein or y-globuin alone. Determinations of both y-globulin and total protei...

In the preceding paper (1)) the isolation, amino acid sequence, and carbohydrate composition of several glycopeptides obtained from rabbit y-globulin were described. In this communication we report the isolation and some properties of glycopeptides from a bovine y-globulin of colostrum and a human Fraction II-3 y-globulin. The amino acid sequence of a glycopeptide from bovine y-globulin has bee...

BACKGROUND Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a common inflammatory neuropathy that can be progressive, stepwise progressive, or relapsing and remitting. OBJECTIVES To further evaluate the long-term safety and tolerability of immune globulin intravenous, 10% caprylate-chromatography purified immune globulin intravenous in CIDP. DESIGN Randomized multicenter ...

This experiment was conducted to determine the blood chemistry and carcass characteristics of broilers fed malted sorghum sprouts (MSP) or wheat offal (W/O)-based diets supplemented with yeast culture enzyme. A total two hundred forty 28-day old, Marshal Broiler chickens used for were randomly allotted 8 dietary treatment groups 30 birds each. Each group replicated thrice 10 per replicate. Data...

Bence-Jones proteins are commonly found in patients with multiple myeloma and have been defined classically' as abnormal urinary proteins that have characteristic thermosolubility properties. Structural studies2 have shown that BenceJones proteins are similar or identical to the light (L) polypeptide chains isolated from the myeloma globulin of the same patient. Taken in conjunction with the re...