Study of the leukemias and polycythemia has been complicated by the inability to isolate pure preparations of suspected "control factors" of hemopoiesis. The presence in rat serum of a factor controlling granulocyte maturation in rat bone-marrow has been demonstrated, but precise analysis has not been possible because of the lack of clear identification of rat-serum proteins. This study analyze...

The genetic factors Gm(a), Gm(b), Gm(x), and Inv(a), Inv(b) described for normal human gamma-globulin were all found in different myeloma proteins. A single myeloma protein never contained more than one product of alternate alleles even in heterozygous individuals. However, factors determined by the two different loci were often found in the same myeloma protein. The Gm(a) character of the myel...

The role of seed proteins, especially soyabean 7S globulins, in controlling dyslipidaemia is widely acknowledged. Amino acid sequence homology among the proteins of this family could reflect similar biological functions in other species. The aim of the present study was to unveil a hypolipidaemic effect of the 7S globulins from cowpeas (7S-C) and adzuki beans (7S-A), administered orally to rats...

Among the substances in mammalian sera that increase vascular permeability under experimental conditions are two globulins, the permeability globulins. The first, kallikrein, was originally described by Frey (2); the second, PF/dil, was first described by Mackay, Miles, Shachter, and Wilhelm (3). The permeability-increasing activity of kallikrein appears to be mediated through the enzymatic gen...

Wit,h the recent import,ant advances in methods of analysis of amino acids, our knowledge of the composition of many types of proteins is being rapidly extended. Microbiological procedures which have come to the fore in recent years provide relatively simple and rapid methods of assay, but strict controls are necessary in order to secure satisfactory results. Frequent checks with protein prepar...

Post-exposure prophylaxis (PEP) against rabies infection consists of a combination of passive immunisation with plasma-derived human or equine immune globulins and active immunisation with vaccine delivered shortly after exposure. Since anti-rabies immune globulins are expensive and scarce, there is a need for cheaper alternatives that can be produced more consistently. Previously, we generated...