Objective(s): Leishmaniasis is one of the main health problems in developing countries, caused by intracellular protozoan parasites of the Leishmania genus. Although research has been successful in discovering vaccines and anti-parasitic drugs like antimony compounds, their side effects like high toxicity, prolonged regeneration, etc., have raised the replacement importance of natural products ...

Cutaneous leishmaniasis (CL) is a serious health challenge at the global level due to Leishmania tropica. This study was conducted to evaluate the risk factors associated with anthroponotic CL (ACL) in unresponsive (patient who does not heal and remains with an active lesion, despite receiving two courses of intra-lesional Glucantime along with cryotherapy and one cycle of systemic Glucantime) ...

this study was carried out to identify the efficacy of caparis spinosa root extract on promastigotes and amastigotes of leishmania major . caparis spinosa extracts were prepared. promastogotes of  l.major (1×10 6 parasites/ml)were incubated at 26 ºc for 24,48 and 72hours in fresh medium(nnn), in absence or presence of different concentrations (0.1,0.3,0.5,0.7,0.9 mg/ml) of caparis spinosa metha...

conclusions according to the current study results, it may be concluded that ethanol extract of p. harmala is efficient in the treatment of cutaneous leishmaniasis, and the efficiency is comparable with that of glucantime. results the results showed that ethanol extract of p. harmala had good therapeutic efficacy in treatment of lesions in mice (p < 0.05), and the efficacy was significant in th...

BACKGROUND Pentavalent antimonials are still the first choice treatment for leishmaniasis, but with low efficacy and resistance is emerging. In the present study, the effect of meglumine antimoniate (MA, Glucantime) combined with paromomycin, miltefosine or allopurinol on in vitro susceptibility of Leishmania tropica resistant isolate was evaluated. METHOD The drugs were obtained from commerc...

the current treatment of choice for cutaneous leishmaniasis is either parenteral or intralesional antimonial compounds. each of these treatments has its own downfalls which include toxic side effects with the parentral injection and pain at the site of injection with the intralesional injection. in recent years, there has been more focus on paromomycin as an alternative drug; however, current d...