BACKGROUND There is a worldwide increase in the prevalence of obesity and disturbances in glucose metabolism. The aim of this study was to assess the current prevalence of obesity, central obesity and abnormal glucose tolerance in Finnish population, and to investigate the associations between body mass index (BMI), waist circumference and abnormal glucose tolerance. METHODS A cross-sectional...

OBJECTIVE Insulin stimulates brain glucose metabolism, but this effect of insulin is already maximal at fasting concentrations in healthy subjects. It is not known whether insulin is able to stimulate glucose metabolism above fasting concentrations in patients with impaired glucose tolerance. RESEARCH DESIGN AND METHODS We studied the effects of insulin on brain glucose metabolism and cerebra...

THE PLASMA GLUCOSE AND BLOOD PYRUVATE LEVELS WERE DETERMINED AFTER ORAL GLUCOSE TOLERANCE TEST IN SIX GROUPS OF WOMEN: non-obese and obese controls and in non-obese and obese women receiving glucocorticoid or oral contraceptive therapy. The mean fasting plasma glucose level was similar in all groups, but glucose tolerance was impaired in the obese controls, non-obese women on oral contraceptive...

The effect of calcitonin on the blood glucose level in glucose-tolerance test of children with the 1-st degree obesity was studied. Initial blood glucose level was normal and glucose-tolerance test per os didn’t expose glucose tolerance impairment in children under control. Calcitonin didn’t change initial glucose concentration but evoked impairment of glucose tolerance. The girls with the 1-st...

OBJECTIVE To determine the population-based prevalence of diabetes and other categories of glucose intolerance (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) in Australia and to compare the prevalence with previous Australian data. RESEARCH DESIGN AND METHODS A national sample involving 11,247 participants aged > or =25 years living in 42 randomly selected areas from th...

In this study, 121 patients who showed diabetic or decreased glucose tolerance and were treated with diet alone for one to fifteen years were investigated as subclinical diabetes. Glucose tolerance in these patients was improved or remained unchanged during the clinical course. Aggravation in glucose tolerance was observed in only seven cases. However, abnormalities in glucose tolerance were st...

The hepatoportal area is an important glucohomeostatic metabolic sensor, sensing hypoglycemia, hyperglycemia, and hormones such as glucagon-like peptide-1 (GLP-1). We have reported previously that activation of hepatoportal sensors by intraportal infusion of glucose and GLP-1 or by subcutaneous administration of GLP-1 receptor activator exenatide and of intraportal glucose improved glycemia ind...

The frequency of glucose intolerance was studied in 106 patients with pulmonary tuberculosis attending Nazimabad Chest Clinic. Diagnosis was based on X-ray and a positive sputum smear. An oral glucose tolerance test (OGTT) was performed and evaluated according to the WHO criteria. Glucose intolerance was detected in 52 (49%) patients, 31 Impaired Glucose Tolerance (IGT), 21 Diabetes Mellitus (D...

AIMS The aim of this study was to estimate the conversion rate to normal glucose tolerance (NGT) from a state of abnormal glucose metabolism and to identify characteristics predicting the conversion rate in first-degree relatives (FDRs) of patients with type 2 diabetes with glucose intolerance. METHODS A total of 2368 (614 men and 1754 women) FDRs of consecutive patients with type 2 diabetes ...