The purpose of this study was to investigate the role of insulin on skeletal muscle GLUT-4 protein expression and glycogen storage after postexercise carbohydrate supplementation. Male Sprague-Dawley rats were randomly assigned to one of six treatment groups: sedentary control (Con), Con with streptozocin (Stz/C), immediately postexercise (Ex0), Ex0 with Stz (Stz/Ex0), 5-h postexercise (Ex5), a...

Type 2 diabetes mellitus is a chronic metabolic disease, characterized by persistent hyperglycemia, the prevalence of which on rise worldwide. Fermented soybean products (FSP) are rich in diverse functional ingredients have been shown to exhibit therapeutic properties alleviating hyperglycemia. This review summarizes hypoglycemic actions FSP from perspective different target-related molecular s...

BACKGROUND Positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism. We have analyzed the effect of solute carrier family 2 (facilitated glucose transporter), member 1 polymorphisms on 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake with a combination of polymorphisms of hy...

Aim To estimate the proportion of individuals with type 2 diabetes mellitus (T2DM) undergoing changes in glucose-lowering therapy 2019 and 2020. Method Individuals T2DM who had at least one consultation 940 general (including diabetologist) practices Germany between January July (N = 79 268) 2020 85 046) were included. Therapy defined as prescription new drugs, or without discontinuation previo...

An online meeting of experts held on November 6, 2020 describes the results EMPA-REG OUTCOME and EMPEROR-Reduced trials sodium-glucose co-transporter-2 (SGLT2) inhibitor empagliflozin. We analyzed cardiovascular renal outcomes in patients with without type 2 diabetes (T2D) receiving A number proposals recommendations have been adopted regarding further study effects empagliflozin its practical ...

The effect of corosolic acid (CA) on blood glucose was studied in KK-Ay mice, an animal model of type 2 diabetes. CA (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, CA did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density micro...

It is generally assumed that there is symmetric distribution of the glucose transporter on the lumenal and ablumenal membranes of the brain capillary endothelial cell that makes up the blood-brain barrier (BBB) in vivo. However, the presence of brain endothelial tight junctions allows for asymmetric distribution of BBB plasma membrane proteins. Glucose transporter isoform 1 (GLUT-1), the princi...

Background: Oleuropein, the main constituent of olive fruit and leaves, has been reported to protect against insulin resistance and diabetes. While many experimental investigations have examined the mechanisms by which oleuropein improves insulin resistance and diabetes, much of these investigations have been carried out in either muscle cell lines or in vivo models two scenarios with many draw...

Aim To explore the effects of second-line combination therapies with metformin on body weight, HbA1c and health-related quality life, as well risks hypoglycaemia further treatment intensification in DISCOVER study, a 3-year, prospective, global observational study patients type 2 diabetes initiating glucose-lowering therapy. Materials Methods Adjusted changes from baseline 36-item Short Form He...