UNLABELLED Structural analysis of the high-mobility group protein B1 (HMGB1)-DNA complex and a docking simulation between glycyrrhetinic acid (GA) and the HMGB1-DNA complex were performed with a software package the Molecular Operating Environment (MOE). An HMGB1-DNA (PDB code: 2GZK) was selected for the 3D structure modeling of the HMGB1-DNA complex. The Site Finder module of the MOE identifie...

Modified chitosan nanoparticles are a promising platform for drug, such as 5-fluorouracil (5-FU), gene, and vaccine delivery. Here, we used chitosan and hepatoma cell-specific binding molecule glycyrrhetinic acid (GA) to synthesize glycyrrhetinic acid-modified chitosan (GA-CTS). The synthetic product was confirmed by infrared spectroscopy and hydrogen nuclear magnetic resonance. By combining GA...

In the last decade, gypsogenin has attracted widespread attention from medicinal chemists by virtue of its prominent anti-cancer potential. Despite late identification, proved itself as a new anti-proliferative player battling for frontline position among other classic pentacyclic triterpenes such oleanolic acid, glycyrrhetinic ursolic betulinic and celastrol. Herein, we present most important ...

Sik,?Lately a patent medicine in the form of pills under the title of " Jintan" is being sold in the market on a very extensive scale. I myself used them as they were very much extolled for sweetening the breath after chewing of pan. After taking the pills three times (as they were sent to me as a specimen) it struck me that it; must be containing a narcotic drug. To-day subjecting it to qualit...

Gastric mucosal cell-derived L-lactic acid strongly enhances proliferation of Helicobacter pylori, and may contribute to the long-term colonization of H. pylori in the stomach. Therefore it is assumed that inhibitory substances active against L-lactic acid-dependent growth of H. pylori will be useful candidates as novel therapeutic agents for H. pylori infection. In this study, we developed a n...