An efficient catalytic asymmetric hetero-ene reaction of 5-methyleneoxazolines with 1,2-dicarbonyl compounds (including α-ketoesters and glyoxal derivatives) was realized using Ni(II)-N,N'-dioxide complexes as the catalysts. It provides a rapid, high yielding (up to 99%) route for the preparation of 2,5-disubstituted oxazole derivatives in a highly enantioenriched form (up to >99% ee) under mil...

Density functional theory calculations demonstrate that Al(III)-catalyzed conversion of glyoxal to glycolic acid proceeds via a 7-membered dual Lewis acid-hydrogen bonding activation transition state of the 1,2-hydride shift, rather than the previously proposed 5-membered metal-alkoxide chelate activation transition state.

BACKGROUND Poly(vinyl alcohol) (PVA) is a synthetic biocompatible polymer that extensively used by the medical and pharmaceutical industries due to its FDA approval for in vivo applications. Its highly hydrophilic nature makes it an ideal wound dressing material, especially form of nanofibrous mats. RESULTS In this work, electrospun PVA-based scaffolds suitable management were created. Chemical...