Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) is predictive for responses to inhaled steroids. We hypothesised that the inflammatory subtype in mild and moderate COPD can be assessed by exhaled breath metabolomics. Exhaled compounds were analysed using gas chromatography and mass spectrometry (GC-MS) and electronic nose (eNose) in 28 COPD patients (12/16 Global Initi...

A gold-catalyzed intramolecular coupling of diazo compounds to produce cyclic olefins has been well established. The medium and large sized membered olefins were obtained in moderate to good yields. Notably, the Z/E selectivity of the olefins highly depended on the ring size. Furthermore, this investigation indicated that the structure of the phosphorous ligand binding to the gold centre played...

Fifteen commercial titania (titanium(iv) oxide; TiO(2)) powders were modified with gold by photodeposition to prepare photocatalysts that work under irradiation with light in the visible range (vis). The gold-modified titania (Au/TiO(2)) powders were characterized by diffuse reflectance spectroscopy (DRS), field-emission scanning electron microscopy (FE-SEM), scanning transmission microscopy (S...

Gold(III) complexes, isostructural and isoelectronic with platinum(II) complexes, are of potential interest as antitumor drugs. We prepared four representative square planar gold(III) complexes – AuCl3(Hpm) , AuCl2(esal) , AuCl(dien) Cl2 and Au(en)2 Cl3 – and characterized them both in the solid state and in solution. Thereafter, the cytotoxicity of these compounds was evaluated in vitro agains...

The synthesis of tetranuclear gold complexes, a structurally unprecedented octanuclear complex with a planar [Au(I) 8 ] core, and pentanuclear [Au(I) 4 M(I) ] (M=Cu, Ag) complexes is presented. The linear [Au(I) 4 ] complex undergoes C-H functionalization of carbonyl compounds under mild reaction conditions. In addition, [Au(I) 4 Ag(I) ] catalyzes the carbonylation of primary amines to form ure...

Recently, gold-carbenoid species have been proposed as intermediates in gold-catalyzed enyne rearrangements.1 Additionally, the reaction of gold complexes with propargyl esters has been developed as an alternative approach to metal carbenoids capable of effecting olefin cyclopropanation;2,3 however, to date, the reaction of electrophilic metals with alkynes has not been amenable to the generati...

Different inorganic and organometallic gold(III) and gold(I) complexes have been tested in the addition of water and methanol to terminal alkynes. Anionic and neutral organometallic gold(III) compounds can efficiently mediate these reactions in neutral media in refluxing methanol. The compounds are added in catalytic amounts (1.6-4.5 mol % with respect to the alkyne). Thus, compounds of the gen...

We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = -OC(O)-p-C6H4-S-) bound to gold(I)-N-heterocyclic carbene fragments through the thiolate group: [(η5-C5H5)2TiMe(μ-mba)Au(NHC)]. The cytotoxicities of the heterometallic compounds along with those of novel monometallic gold-N-heterocyclic carbe...

Stimulated by the interest in developing gold compounds for treating cancer, gold ion-angiotensin peptide interactions are investigated by mass spectrometry. Under the experimental conditions used, the majority of gold ion-angiotensin peptide complexes contain gold in the oxidation states I and III. Both ESI-MS and MALDI-TOF MS detect singly/multiply charged ions for mononuclear/multinuclear go...

Solok Selatan is already known as an area that has potential precious metal, Gold. Local mining scale can be found on site certain areas in Abai Region, especially the North, which was previously believed to exist presence of these minerals. Based consideration associated mineral associations gold, course other metals deserves further investigation such Copper (Cu), Silver (Ag), Lead (Pb), Zinc...