Abstract We describe a simple method for the preparation of gold-decorated silica (SiO 2 ) nanoparticles (NPs) by in situ precipitation using BH 4 − ions reduction as procedure, where are adsorbed onto PEI-functionalized SiO NPs stabilizing and reducing gold PEI-SiO surface water under ambient conditions. The result was 3-nm nanoshell attached to core (~ 75 nm) with plasmon resonance (SPR) at ~...

The aim of this study is to report a case of gold shunt surgery for uncontrolled, low-tension glaucoma with good central vision, after having a previously failed trabeculectomy and tube shunt surgeries. The patient was receiving maximum medical glaucoma therapy of four different types with intraocular pressure of 17 mm Hg prior to gold shunt surgery. Five years later, intraocular pressure is we...

Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-phase clinical trials. In particular, the pre-clinical evidence for gold nanoparticles as sensitis...

SIR, There are important differences between the study of Ishigami et al and our report' which may explain the apparently discordant findings. Ishigami's study included 58 patients treated with gold over a 12 month period. Although we are not told, one assumes that the gold preparation and the dose schedule used were similar in both studies. In Ishigami's study gold therapy was 'considered succ...

B-Chronic Lymphocytic Leukemia (CLL) is an incurable disease predominantly characterized by apoptosis resistance. We have previously described a VEGF signaling pathway that generates apoptosis resistance in CLL B cells. We found induction of significantly more apoptosis in CLL B cells by co-culture with an anti-VEGF antibody. To increase the efficacy of these agents in CLL therapy we have focus...

Plasmonic nanostructures capable of converting light to heat have found wide applications, thus giving rise the field thermoplasmonics. Among them, use gold-based plasmonic structures in near-infrared (NIR) spectral regions has catalyzed substantial research efforts due potential impact clinical therapy applications. However, photon scattering effect scaling with square nanoparticle volume lead...

Acoustic cavitation which occurs at high intensities of ultrasound waves can be fatal for tumor cells. The existence of dissolved gases and also the presence of nanoparticles (NPs) in a liquid, irradiated by ultrasound, decrease the acoustic cavitation onset threshold and the resulting bubbles collapse. On the other hand, due to unique capabilities and optical properties of gold nanoparticles (...

Twenty patients undergoing treatment with aurothiomalate for rheumatoid arthritis (RA) were studied for the presence of gold in all urine specimens passed over four days and for gold in the serum of blood drawn by venous section at 10.00, 16.00, and 22.00 hours on a single day of the study. Specimens of saliva collected at the same times as the blood specimens were also analysed for (total) gol...

Mice bearing subcutaneous EMT-6 mammary carcinomas received a single intravenous injection of 1.9 nm diameter gold particles (up to 2.7 g Au/kg body weight), which elevated concentrations of gold to 7 mg Au/g in tumours. Tumour-to-normal-tissue gold concentration ratios remained approximately 8:1 during several minutes of 250 kVp x-ray therapy. One-year survival was 86% versus 20% with x-rays a...

There has been much interest in developing a thin-film solar cell because it is lightweight and flexible. The GaAs thin-film solar cell is a top contender in the thin-film solar cell market in that it has a high power conversion efficiency (PCE) compared to that of other thin-film solar cells. There are two common structures for the GaAs solar cell: n (emitter)-on-p (base) and p-on-n. The forme...