AIMS Establishing biochemical markers of pre-hypertension and early hypertension could help earlier diagnostics and therapeutic intervention. We assess dynamics of junctional adhesion molecule-A (JAM-A) expression in rat models of hypertension and test whether JAM-A expression could be driven by angiotensin (ANG) II and whether JAM-A contributes to the progression of hypertension. We also compa...

THE ROLE of the kidney in the regulation of arterial pressure was recognized as early as 1898 when Tigerstedt and Bergman demonstrated that kidney extracts possess a pressor action and gave the name renin to the substance producing the action. In 1934. Goldblatt and co-workers' produced chronic renal hypertension in dogs by renal artery constriction. This discovery was a major breakthrough beca...

Despite extensive use of the renovascular/Goldblatt model of hypertension-2K-1C, and the use of renal denervation to treat drug resistant hypertensive patients, autonomic mechanisms that underpin the maintenance of this hypertension are important yet remain unclear. Our aim was to analyse cardiovascular autonomic function by power spectral density analysis of both arterial pressure and pulse in...

Chromogranins A and B are major soluble proteins in chromaffin granules. Their adrenomedullary content is increased in the spontaneously (genetic) hypertensive rat. Is augmented catecholamine vesicular storage of the chromogranins a specific feature of genetic hypertension? To explore this question, we measured chromogranin A immunoreactivity, using a novel, synthetic peptide radioimmunoassay, ...

Reactive oxygen species in peripheral cardiovascular tissues are implicated in the pathogenesis of 2 kidney-1 clip hypertension. We recently identified an imbalance between reactive oxygen species generation and oxidant scavenging in the rostral ventrolateral medulla (RVLM) of 2 kidney-1 clip in rats. We tested whether enhanced superoxide signaling in RVLM of 2 kidney-1 clip rats contributes to...

1. Reduction of renal perfusion pressure from 133 mmHg to 117 mmHg in control rats did not induce a significant change of kidney glomerular filtration rate (GFR) or nephron GFR determined in distal tubules. In contrast, nephron GFR measured in proximal tubular segments (NGFR-P) fell significantly. 2. Qualitatively the same response of filtration rate to changes of arterial blood pressure was fo...

The celebrated theorem proved by Goldblatt and Thomason in 1974 gives necessary and sufficient conditions for an elementary (i.e., first-order definable) class of Kripke frames to be modally definable. Here we obtain a local analogue of this result, where in place of frames we consider n-frames, which are frames with n distinguished worlds. For talking about n-frames, we generalize customary mo...

The effect of reversal of hypertension on vascular function and composition was investigated in renal-hypertensive rats. The study comprised three groups of rats: 1) 21 male Sprague-Dawley rats with one-kidney, one clip Goldblatt hypertension of 9 weeks' duration; 2) 20 rats with one-kidney, one clip hypertension that underwent removal of renal artery clip (were "unclipped") at 6 weeks of hyper...

Several laboratories have reported evidence suggesting that in hypertension there are abnormalities in the activity of the sarcolemmal sodium pump in vascular smooth muscle. In the present study, by sampling tissue from both hypertensive and normotensive portions of the arterial tree in coarctation hypertension, we investigated the relationship of such abnormalities to the elevated intravascula...