Experimental transmission of the Stetsonville, Wisconsin, U.S.A. source of transmissible mink encephalopathy (TME) to outbred Syrian golden hamsters resulted in two distinct syndromes, termed hyper (HY) and drowsy (DY), that diverge by the third hamster passage. The syndromes differed with respect to clinical signs, incubation period, brain titre, brain lesion profile and pathogenicity in mink....

Previous work on the early development of the golden hamster includes the investigation of Ochs (1908), Graves (1945) and Ward (1948), all at the level of the light microscope. Austin (1963) has examined the ultrastructure of the oocytes of the golden hamster while Enders & Schlafke (1965) have observed the pre-implantation stages of pregnancy. The ultrastructure of implantation has been studie...

A pancreatic acinar cell-mediated mutagenicity assay was developed as an in vitro model system to study the metabolism of N-nitrosobis(2-oxopropyl)amine (BOP) and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amino (HPOP) into forms mutagenic for Chinese hamster V79 cells. Mutations at the hypoxanthine:guanine phosphoribosyltransferase locus and the Na/K ATPase locus were scored by resistance to 6-thi...

The carcinogens 9,10-dime thy 1-1,2-benzanthracene, 20-methylcholanthrene, 3,4benzpyrene, 1,2,5,6-dibenzanthracene, 1,2-benzanthracene, and 2-anthramine have been tested topically in the Syrian golden hamster. The mouse skin tumor-promoting agents, croton oil and polyoxyethylene sorbitan monostearate (Tween 60), have been tested on hamster skin following a single applica tion of 9,10-dimethyl-l...

Introduction. The appearance of a coloboma of the iris must have been known long before Walther (15) introduced the term in 1821 since the condition is easiiy visible. The word coloboma is derived from the Greek and means the part which is taken away in mutilation or injury or the part that is lacking, that is, a defect. In coloboma iridis, therefore, a section of the iris is lacking, often bil...

A. number of clinical statistical studies con ducted in recent years have pointed to an associa tion between several environmental factors and an increase in the incidence of bronchogenic car cinoma in man (7). Of the numerous factors in volved, atmospheric pollution and cigarette smok ing are being considered with the most seriousness (4, 6, 8, 9, 15). To supplement the clinical data, experime...