Good Clinical Practice (GCP) is an international ethical and scientific quality standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials. It also serves to protect the rights, integrity and confidentiality of trial subjects. It is very important to understand the background of the formation of the ICH-GCP guidelines as this, in it...

Alex McMahon and colleagues critique the International Conference on Harmonisation (ICH) guidance on good clinical practice (GCP), arguing that it is having a disastrous effect on noncommerical randomized clinical trials in Europe.

PURPOSE Evaluate contact lenses fitting after intracorneal ring implantation for keratoconus, its visual acuity and comfort. METHODS Retrospective study of patients undergoing contact lenses fitting, after intracorneal ring for keratoconus. The criterion for contact lens fitting was unsatisfactory visual acuity with spectacle correction as referred by the patients. All patients were intoleran...

a 25 year-old construction worker underwent neck laceration following penetrating neck trauma in a falling incident. the 3rd tracheal ring was injured which was initially repaired and the patient was discharged in good general condition. (figure 1 shows the patient’s neck view after discharge from hospital).two months later the patient was again admitted due to provocative coughing and a metal ...

1-carboxymethyl-3-methylimidazolium chloride {[cmmim]cl} is utilized as a highly efficient and reusable catalyst for the synthesis of bis(indolyl)methanes by the condensation reaction of indole with arylaldehydes under solvent-free conditions at room temperature. in summary, the presented method have several advantages including simplicity, low cost, generality, efficiency, clean reaction profi...

The fallacy of the popular concept that "it's good enough for clinical purposes" is becoming more widely recognized as the potentialities of scientific methods in diagnosis and therapy increase. Such a manual as this should aim to raise the dignity and improve the quality of clinical chemistry and clinical chemists, not, by conceding to prevailing opinion, perpetuate its present mediocre estate...

1 Ethno Medicines of Kolli Hills at Namakkal District in Tamilnadu and its significance in Indian Systems of Medicine G.Arunachalam, M.Karunanithi N.Subramanian, V.Ravichandran and S.Selvamuthukumar PGP College of Pharmaceutical Science and Research Institute, NH -7, Namakkal Karur Main Road, Namakkal – 637297, Tamilnadu, India. Department of CARISM, SASTRA University, Thanjavur 613402, Tamilna...

The design of a complex regulator often includes the making of a model of the system to be regulated. The making of such a model has hitherto been regarded as optional, as merely one of many possible ways. m this paper a theorem is presented which shows, under very broad conditions, that any regulator that is maximally both successful and simple must be isomorphic with the system being regulate...

Starting from readily available phenanthrenequinone and alkenes, biaryl containing medium-ring bislactones could be easily prepared through sequential photocycloaddition-photooxidation reactions with good yields and diastereoselectivity.

in this paper we prove that each element of any regular baer ring is a sum of two units if no factor ring of r is isomorphic to z_2 and we characterize regular baer rings with unit sum numbers $omega$ and $infty$. then as an application, we discuss the unit sum number of some classes of group rings.