Since their inception in 1994, design patterns have been the subject of many papers. In the reverse-engineering community, several authors have proposed approaches to consider design patterns during reverseand re-engineering. However, it has been recently put forward in the community that it is difficult to compare previous approaches due to the diversity of vocabulary and the lack of a general...

BACKGROUND AND AIMS Lupus nephritis (LN), with considerable morbidity and mortality, is one of the most severe manifestations of systemic lupus erythematosus (SLE). Yet, the pathogenic mechanisms of LN have not been clearly elucidated, and efficient therapies are still in great need. Granulin (GRN), a multifunctional protein linked to inflammatory diseases, has recently been reported to correla...

Bayesian models of cognition and behavior are particularly promising when they are used in reverse-engineering explanations: explanations that descend from the computational level of analysis to the algorithmic and implementation levels. Unfortunately, it remains unclear exactly how Bayesian models constrain and influence these lower levels of analysis. In this paper, we review and reject two w...

We present an integrated system to automatically generate computer-aided design (CAD) models of existing vehicle parts using laser range imaging techniques. The proposed system integrates data acquisition, model reconstruction, and post processing to generate a set of models from real-world automotive parts. This range image-based, computer-aided reverse engineering (CARE) system has potential ...

Alteration of the functional organization of the gene regulatory networks (GRNs) that control development of the body plan causes evolutionary change in animal morphology. A major mechanism of evolutionary change in GRN structure is alteration of cis-regulatory modules that determine regulatory gene expression. Both evolutionary conservation and evolutionary innovation must be considered in ter...

BACKGROUND Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of sporadic FTLD is unclear. RESULTS We analyzed whether DNA methylation in the GRN core promoter r...

The past decade has assisted to a growing interest in reverse engineering and to the consequent proliferation of papers and experience reports about this subject from both academic and industrial environments. Many types of reverse engineering process components (i.e. methods, algorithms, techniques, procedures, processes model, etc.) have been proposed. To be able to reuse effectively the publ...

Reverse engineering and software evolution are probably today among the most challenging research areas in software engineering. They are also very rich fields for applying model engineering techniques. However, in order to define a sound model-driven reverse engineering framework, we need to understand more clearly the conditions under which various abstract models may be extracted from legacy...

In this paper, we suggest a new approach for reverse engineering gene regulatory networks, which consists of using a reconstruction process that is similar to the evolutionary process that created these networks. The aim is to integrate prior knowledge into the reverse-engineering procedure, thus biasing the search toward biologically plausible solutions. To this end, we propose an evolutionary...

With the evolving needs of today’s manufacturing industries in the area of product development, 3D CAD model has become very important. Often in many situations there is a need to remanufacture a physical part where the CAD data is not available with the manufacturer or is lost because of several reasons. In such cases reverse engineering is found to be an effective and efficient tool. Reverse ...