نتایج جستجو برای: h marinum
تعداد نتایج: 531781 فیلتر نتایج به سال:
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferase (NAT), an enzyme essential for mycobacterial survival inside macrophages. The NAT inhibition involves a prodrug-like mechanism in which acti...
Drosophila melanogaster infected with Mycobacterium marinum suffer metabolic wasting similar to that seen in humans suffering from tuberculosis. This wasting is linked to insulin signaling and hastens host death.
We report a case of osteomyelitis and synovitis produced by Mycobacterium marinum in the left index finger of a fisherman. A combination of surgical intervention and antimicrobial therapy with minocycline, rifampin, and ethambutol was efficacious.
The hallmark of tuberculosis (TB) is the formation of granulomas, which are clusters of infected macrophages surrounded by additional macrophages, neutrophils and lymphocytes. Although it has long been thought that granulomas are beneficial for the host, there is evidence that mycobacteria also promote the formation of these structures. In this study, we aimed to identify new mycobacterial fact...
We recently identified two loci, mel1 and mel2, that affect macrophage infection by Mycobacterium marinum. The ability of these loci to confer enhanced infection in trans is presumably due to gene dosage effects since their presence on plasmids increases expression from five- to eightfold. Reasoning that this phenomenon would allow identification of other mycobacterial genes involved in macroph...
Mycobacterium marinum causes long-term subclinical granulomatous infection in immunocompetent leopard frogs (Rana pipiens). These granulomas, organized collections of activated macrophages, share many morphological features with persistent human tuberculous infection. We examined organs of frogs with chronic M. marinum infection using transmission electron microscopy in conjunction with immunoh...
The causative agent of tuberculosis (TB), Mycobacterium tuberculosis, remains an important worldwide health threat. Although TB is one of the oldest infectious diseases of man, a detailed understanding of the mycobacterial mechanisms underlying pathogenesis remains elusive. Here, we studied the role of the α(1→2) mannosyltransferase MptC in mycobacterial virulence, using the Mycobacterium marin...
Mycobacterium marinum is a photochromogenic myco bacterium capable of indu c in g a se lflimitin g loca li zed infection within the mouse foot pad ( 1.4 ). Because this infection is íwalogous to the M. leprae infection in the mouse, it has been suggested as an a lternative experimenta l model for studying the role of host immunity to M. leprae infection in the mouse foot pad (1 2. 16. 19). Pres...
Sporotrichoid presentation of Mycobacterium marinum infection of the upper extremity. A case report.
BACKGROUND Mycobacterium marinum is a human opportunistic pathogen that is known to inhabit swimming pools, home aquariums, and natural bodies of salt and fresh water. Epidemic cases involving swimming pools are easily recognized, but sporadic cases are frequently misdiagnosed. OBJECTIVE A 42-year-old male presented with a 2-month history of the appearance of livid, verrucous, painless nodule...
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