SummaryBackground Urinary tract infections (UTIs) are among the most common hospital-acquired infections, with an estimated 75% of UTIs caused by urinary catheters. In addition to significant healthcare costs and patient morbidity, escalating antimicrobial resistance reported uropathogens make investigation efficacious new strategies urgent importance. Aim To examine ...

AbstractIntroduction Epilepsy is a chronic neurological disorder that may occur alongside cognitive changes, with effects on multiple domains. Objective To compare the performance of patients epilepsy and healthy controls through Montreal Cognitive Assessment (MoCA) during outpatient consultation at reference diagnostic center in Colombia analyze influencing factors. ...

Background: Evidence supports the clinical effectiveness of intimate partner violence (IPV) screening programs, but less is known about implementing and sustaining them. This qualitative study identified implementation strategies used to integrate IPV programs within Veterans Health Administration (VHA) women9s health primary care. Methods: Thirty-two administrators clinician ...

AbstractPurpose To examine the fidelity of our model laparoscopic inguinal hernia repair (LIHR) in boys and evaluate its value resident training programs learning basic laparoscopy skills. Methods We created a simulation with inexpensive, easy-to-obtain equipment. Study participants from 34 university hospital departments received user manual an evaluation questionnai...

Context: UK Biobank is increasingly used to study causes, associations, and implications of multimorbidity. However, criticised for lack representativeness ‘healthy volunteer bias’. Selection bias can lead spurious or biased estimates associations between exposures outcomes. Objectives: To compare association multimorbidity adverse health outcomes in a nationally representativ...

Context: Frailty is common in people with COPD, however definitions of frailty are highly variable. Understanding prevalence, trajectories and outcomes associated important to inform interventions clinical management. Objective: This systematic review synthesizes the measurement prevalence within-person over time, associations between adverse health COPD. Study design:</h3...

Importance The prevalence of overweight and obesity is increasing among persons childbearing age pregnant persons. In 2015, almost half all began pregnancy with (24%) or (24%). Reported rates are higher Black, Alaska Native/American Indian, Hispanic women lower White Asian women. Excess weight at the beginning excess gestational gain have been associated adverse maternal infant health ...

Very little is known about the role of histone H3 phosphorylation in malignant transformation and cancer development. Here, we examine the function of H3 phosphorylation in cell transformation in vivo. Introduction of small interfering RNA-H3 into JB6 cells resulted in decreased epidermal growth factor (EGF)-induced cell transformation. In contrast, wild-type histone H3 (H3 WT)-overexpressing c...

AIMS Hepatic stellate cells (HSCs) play critical roles in the development of hepatic fibrosis caused by various agents including alcohol. Ethanol causes post-translational modification in histone. The goal of this study is to investigate whether ethanol affected acetylation and methylation of histone H3 in rat HSCs. METHODS We isolated and separated HSCs using collagenase perfusion of liver f...